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5,6-dihydro-5-Fluorouracil

Catalog No. T36870 CAS 696-06-0

Synonyms: 5-fluorodihydrouracil, 5-Fluoro-dihydro-pyrimidine-2,4-dione

5,6-dihydro-5-Fluorouracil (5-FUH2) is an inactive metabolite of 5-FU and can be used for the study of organismal metabolism.

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5,6-dihydro-5-Fluorouracil Chemical Structure

5,6-dihydro-5-Fluorouracil, CAS 696-06-0

Pack Size	Availability	Price/USD
5 mg	35 days	$ 223.00
10 mg	35 days	$ 423.00
25 mg	35 days	$ 980.00
50 mg	35 days	$ 1,880.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	5,6-dihydro-5-Fluorouracil (5-FUH2) is an inactive metabolite of 5-FU and can be used for the study of organismal metabolism.
Targets&IC50	MDA-MB-231 cells:0.25 μg/mL
In vitro	The combination of 5,6-dihydro-5-Fluorouracil (5-Fu) and NSC 123127 (Dox) demonstrates synergistic anticancer efficacy. The IC50 values for 5-Fu/Dox-DNM against human breast cancer (MDA-MB-231) cells are 0.25 μg/mL, with cytotoxicity increasing by 11.2-fold and 6.1-fold for Dox-DNM and 5-Fu-DNM, respectively [4]. In NFBD1-inhibited NPC cells treated with 5,6-dihydro-5-Fluorouracil (5-FU) and CDDP, lentivirus-mediated short hairpin RNA depletion of NFBD1 expression in NPC CNE1 cell line enhances sensitivity. Knockdown of NFBD1 significantly induces apoptosis in CNE1 cells treated with CDDP or 5,6-dihydro-5-Fluorouracil [2].
In vivo	Administered at a dose of 23 mg/kg three times a week for 14 days, 5,6-dihydro-5-Fluorouracil(5-FU) induces gastrointestinal transit acceleration associated with acute intestinal inflammation starting on the third day of treatment. This may lead to sustained changes in the enteric nervous system (ENS) observed beyond the 7th day, and the 14-day treatment results in delayed gastrointestinal transit and colonic motility disorders [1].

Synonyms	5-fluorodihydrouracil, 5-Fluoro-dihydro-pyrimidine-2,4-dione
Molecular Weight	132.09
Formula	C4H5FN2O2
CAS No.	696-06-0

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 43 mg/mL(325.53 mM), Sonication is recommended.

PBS (pH 7.2): 8 mg/mL

Ethanol: 0.8 mg/mL

DMF: 60 mg/mL

References and Literature

1. McQuade RM, et al. Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer chemotherapeutic agent 5-fluorouracil. Neurogastroenterol Motil. 2016 Jun 28. 2. Zeng Q, et al. Knockdown of NFBD1/MDC1 enhances chemosensitivity to NSC 119875 or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells. Mol Cell Biochem. 2016 Jul;418(1-2):137-46. 3. Jones DH, et al. Ten-Year and Beyond Follow-up After Treatment With Highly Purified Liquid-Injectable Silicone for HIV-Associated Facial Lipoatrophy: A Report of 164 Patients. Dermatol Surg. 2019 Jul;45(7):941-948. 4. Han R, et al. Amphiphilic dendritic nanomicelle-mediated co-delivery of 5-fluorouracil and NSC 123127 for enhanced therapeutic efficacy. J Drug Target. 2016 Jun 29:1-28.

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Keywords

5,6-dihydro-5-Fluorouracil 696-06-0 Others 5,6dihydro5Fluorouracil 5-fluorodihydrouracil 5-Fluoro-dihydro-pyrimidine-2,4-dione 5,6 dihydro 5 Fluorouracil inhibitor inhibit

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