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(Z)-PUGNAc

Name: (Z)-PUGNAc
Brand: TargetMol
SKU: T38722
Price: 66 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T38722Cas No. 132489-69-1

(Z)-PUGNAc, a potent O-GlcNAcase inhibitor more active than (E)-PUGNAc, removes O-GlcNAc from proteins (peptide O-GlcNAc-β-N-acetylaminoglucosidase) and can be used to increase levels of O-GlcNAc on nuclear and cytoplasmic proteins in vivo.

(Z)-PUGNAc

🥰Excellent

Purity: 97.58%

Catalog No. T38722Cas No. 132489-69-1

Pack Size	Price	Availability
1 mg	$66	In Stock
5 mg	$158	In Stock
10 mg	$293	In Stock
25 mg	$497	In Stock
50 mg	$726	In Stock
100 mg	$980	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.58%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	(Z)-PUGNAc, a potent O-GlcNAcase inhibitor more active than (E)-PUGNAc, removes O-GlcNAc from proteins (peptide O-GlcNAc-β-N-acetylaminoglucosidase) and can be used to increase levels of O-GlcNAc on nuclear and cytoplasmic proteins in vivo.
In vitro	In HeLa and HEK cell systems, (Z)-PugNAc amplifies the incorporation of O-GlcNAc onto proteins[1].

Chemical Properties

Molecular Weight	353.33
Formula	C₁₅H₁₉N₃O₇
Cas No.	132489-69-1
Smiles	CC(=O)NC1C(O)C(O)C(CO)OC1=NOC(=O)Nc1ccccc1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (28.30 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8302 mL	14.1511 mL	28.3022 mL	141.5108 mL
5 mM	0.5660 mL	2.8302 mL	5.6604 mL	28.3022 mL
10 mM	0.2830 mL	1.4151 mL	2.8302 mL	14.1511 mL
20 mM	0.1415 mL	0.7076 mL	1.4151 mL	7.0755 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc