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(+)-Coclaurine

Name: (+)-Coclaurine
Brand: TargetMol
SKU: T5766
Rating: 4.5 (1 reviews)

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Catalog No. T5766Cas No. 2196-60-3

Alias Coclaurine

(+)-Coclaurine is a natural product.

(+)-Coclaurine

Copy Product Info

😃Good

Catalog No. T5766Alias CoclaurineCas No. 2196-60-3

(+)-Coclaurine is a natural product.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$483	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	(+)-Coclaurine is a natural product.
In vivo	Coclaurine 25 ug produced an inhibition of locomotor activity, ptosis and catalepsy. One hour after injection it produced stereotyped behaviour,such as sniffing and gnawing.Pretreatment with coclaurine 25 ug suppressed locomotor activation and rotational behaviour induced by apomorphine and methamphetamine.
Synonyms	Coclaurine

Chemical Properties

Molecular Weight	285.34
Formula	C₁₇H₁₉NO₃
Cas No.	2196-60-3
Smiles	C([C@@H]1C=2C(=CC(OC)=C(O)C2)CCN1)C3=CC=C(O)C=C3
Relative Density.	1.232g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (157.71 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5046 mL	17.5230 mL	35.0459 mL	175.2296 mL
5 mM	0.7009 mL	3.5046 mL	7.0092 mL	35.0459 mL
10 mM	0.3505 mL	1.7523 mL	3.5046 mL	17.5230 mL
20 mM	0.1752 mL	0.8761 mL	1.7523 mL	8.7615 mL
50 mM	0.0701 mL	0.3505 mL	0.7009 mL	3.5046 mL
100 mM	0.0350 mL	0.1752 mL	0.3505 mL	1.7523 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

postsynapticInhibitorinhibitd-CoclaurineBenzyltetrahydroisoquinolinealkaloid(R)-Coclaurine(+)-Coclaurine(+)Coclaurine(+) Coclaurine