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STIM1-TFR1-IN-1
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Catalog No. T218556 Copy Product Info
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STIM1-TFR1-IN-1 is an inhibitor of the stromal interaction molecule 1-transferrin receptor 1 (STIM1-TFR1) protein complex, demonstrating a dissociation constant (Kd) of 2.18 μM with STIM1-CD protein. This compound disrupts the interaction between STIM1 and TFR1, thereby reducing TFR1-mediated iron uptake activity. It also inhibits ferroptosis, lipid peroxidation, and the production of reactive oxygen species (ROS), while enhancing the activity of glutathione peroxidase 4 (GPX4) and the glutathione/oxidized glutathione ratio, effectively reversing ferroptosis-associated mitochondrial morphological changes. Additionally, STIM1-TFR1-IN-1 provides neuroprotection and mitigates brain injury, making it a valuable tool for intracerebral hemorrhage research.
STIM1-TFR1-IN-1
Cas No. 2196106-61-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | STIM1-TFR1-IN-1 is an inhibitor of the stromal interaction molecule 1-transferrin receptor 1 (STIM1-TFR1) protein complex, demonstrating a dissociation constant (Kd) of 2.18 μM with STIM1-CD protein. This compound disrupts the interaction between STIM1 and TFR1, thereby reducing TFR1-mediated iron uptake activity. It also inhibits ferroptosis, lipid peroxidation, and the production of reactive oxygen species (ROS), while enhancing the activity of glutathione peroxidase 4 (GPX4) and the glutathione/oxidized glutathione ratio, effectively reversing ferroptosis-associated mitochondrial morphological changes. Additionally, STIM1-TFR1-IN-1 provides neuroprotection and mitigates brain injury, making it a valuable tool for intracerebral hemorrhage research. |
| In vitro | STIM1-TFR1-IN-1 (Compound S-IN-1) at concentrations of 0.15625-5 μM directly and selectively binds to the STIM1-CD protein, with a dissociation constant (K d) of 2.18 μM. At concentrations of 10-20 μM, S-IN-1 inhibits the interaction between STIM1 and TFR1 in HT22 mouse neuronal cells exposed to Hemin to simulate intracerebral hemorrhage (ICH). Furthermore, S-IN-1 at 0-40 μM alleviates neuronal ferroptosis and enhances neuronal cell viability in Hemin-treated HT22 mouse neuronal cells by reducing iron accumulation, lipid peroxidation, and ROS, while boosting the antioxidant defense system. |
| In vivo | STIM1-TFR1-IN-1 (Compound S-IN-1) administered orally at a dosage of 10 mg/kg once every 24 hours significantly reduces brain tissue damage in a mouse model of cerebral hemorrhage, while continuously improving sensory, motor, and cognitive neurological deficits. |
| Molecular Weight | 319.43 |
| Formula | C15H21N5OS |
| Cas No. | 2196106-61-1 |
| Smiles | [C@@H](C(NC=1NC(=NN1)C2CCC2)=O)(CCSC)N3C=CC=C3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: STIM1-TFR1-IN-1 in vivo | STIM1-TFR1-IN-1 in vitro | STIM1-TFR1-IN-1 formula | STIM1-TFR1-IN-1 molecular weight
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