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S1R agonist 3
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Catalog No. T218821 Copy Product Info
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S1R agonist 3 is a potent and selective sigma-1 receptor (S1R) agonist with a Ki of 1.5 nM. It reduces hyperactive behavior in wfs1abKO zebrafish larvae without affecting the motor skills of wild-type wfs1abWT larvae. Additionally, S1R agonist 3 can reverse learning and memory impairment induced by Aβ25-35. S1R ligand 1 is applicable for Alzheimer's disease research.
S1R agonist 3
Cas No. 401501-66-4
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | S1R agonist 3 is a potent and selective sigma-1 receptor (S1R) agonist with a Ki of 1.5 nM. It reduces hyperactive behavior in wfs1abKO zebrafish larvae without affecting the motor skills of wild-type wfs1abWT larvae. Additionally, S1R agonist 3 can reverse learning and memory impairment induced by Aβ25-35. S1R ligand 1 is applicable for Alzheimer's disease research. |
| Targets & IC50 | Sigma 1 Receptor:1.5 nM (Ki) |
| In vitro | S1R agonist 3 (Compound 1) binds effectively to the S1R on transfected HEK293 cell membranes with a K i value of 1.5 ± 0.5 nM at concentrations ranging from 0.01-10000 nM over 120 minutes. Additionally, S1R agonist 3 acts as a potent S1R agonist in overexpressed CHO cells, inducing S1R-BiP dissociation with an EC 50 of 160 ± 8 nM at concentrations of 0.01-1 μM over 30 minutes. |
| In vivo | S1R agonist 3 (Compound 1), at a concentration of 3 μM over 24 hours, effectively suppresses hyperactivity in wfs1abKO zebrafish larvae without affecting the normal movement of wild-type larvae. Additionally, S1R agonist 3 administered intraperitoneally at 0.03 mg/kg as a single dose, 20 minutes after Aβ 25-35 injection, strongly reverses learning and memory deficits induced by Aβ 25-35 in mice. |
| Molecular Weight | 253.77 |
| Formula | C14H20ClNO |
| Cas No. | 401501-66-4 |
| Smiles | ClC1=CC=C(OCCN2CCC(C)CC2)C=C1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Related Tags: S1R agonist 3 in vivo | S1R agonist 3 in vitro | S1R agonist 3 formula | S1R agonist 3 molecular weight
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