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rac-CCT-250863 HCl

Name: rac-CCT-250863 HCl
Brand: TargetMol
SKU: T28498L
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T28498L

Alias rac-CCT-250863 HCl(1364269-06-6 Free base)

rac-CCT-250863 HCl is a selective and reversible inhibitor of NEK 2. rac-CCT-250863 HCl induces cell cycle arrest and has good anti-proliferative activity against cancer cells. rac-CCT-250863 HCl can be used in combination with Pomalidomide to induce apoptosis and can be used in combined anti-cancer studies.

rac-CCT-250863 HCl

😃Good

Purity: 98.21%

Catalog No. T28498LAlias rac-CCT-250863 HCl(1364269-06-6 Free base)

Pack Size	Price	Availability
1 mg	$195	Backorder
5 mg	$440	Backorder
50 mg	$1,390	Backorder
1 mL x 10 mM (in DMSO)	$552	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.21%

Resource Download

COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	rac-CCT-250863 HCl is a selective and reversible inhibitor of NEK 2. rac-CCT-250863 HCl induces cell cycle arrest and has good anti-proliferative activity against cancer cells. rac-CCT-250863 HCl can be used in combination with Pomalidomide to induce apoptosis and can be used in combined anti-cancer studies.
Targets&IC50	K12PE:8.7 μΜ, AMOL:7.1 μΜ, H929 multiple myeloma cell lines:8.0 μΜ, NEK2:0.073 µM
Synonyms	rac-CCT-250863 HCl(1364269-06-6 Free base)

Chemical Properties

Molecular Weight	527
Formula	C₂₄H₂₆ClF₃N₄O₂S
Smiles	NC1=C(C=C(C=N1)C2=CC(CN(C)C)=CS2)C3=CC(OC(/C=C\C(F)(F)F)C)=C(C(N)=O)C=C3.Cl
Relative Density.	no data available
Color	Orange
Appearance	Oil

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (42.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8975 mL	9.4877 mL	18.9753 mL	94.8767 mL
5 mM	0.3795 mL	1.8975 mL	3.7951 mL	18.9753 mL
10 mM	0.1898 mL	0.9488 mL	1.8975 mL	9.4877 mL
20 mM	0.0949 mL	0.4744 mL	0.9488 mL	4.7438 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc