Shopping Cart
Remove All
Your shopping cart is currently empty
GPX4 degrader-1
Copy Product Info
🥰Excellent
Synonyms:
Catalog No. T218128 Copy Product Info
🥰Excellent
GPX4 degrader-1 (Compound RS-1) is a GPX4 degrader utilizing hydrophobic tag (HyT) technology, demonstrating a DC50 of 8.9 nM in HT1080 cells. It induces GPX4 degradation, triggers ferroptosis, and increases lipid ROS levels. In a mouse breast cancer model, GPX4 degrader-1 exhibits potent antitumor activity.
GPX4 degrader-1
Cas No. 3057531-85-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Quotation
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
Resource Download
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | GPX4 degrader-1 (Compound RS-1) is a GPX4 degrader utilizing hydrophobic tag (HyT) technology, demonstrating a DC50 of 8.9 nM in HT1080 cells. It induces GPX4 degradation, triggers ferroptosis, and increases lipid ROS levels. In a mouse breast cancer model, GPX4 degrader-1 exhibits potent antitumor activity. |
| Targets & IC50 | GPX4:8.9 nM (DC50) |
| In vitro | GPX4 degrader-1 induces dose- and time-dependent, proteasome-mediated degradation of GPX4 in HT1080 fibrosarcoma cells, with a DC50 of 8.9 nM, when used at concentrations of 0.3-300 nM for 2-48 hours. After 48 hours of treatment, GPX4 degrader-1 promotes ferroptosis-mediated antiproliferative activity in cancer cell lines HT1080, A549, and 4T1, with IC50 values of 130 nM, 6.4 μM, and 700 nM, respectively. Additionally, GPX4 degrader-1, at concentrations of 0.5-2.0 μM for 24-48 hours, increases lipid ROS and MDA levels in HT1080 fibrosarcoma cells. |
| In vivo | In a 4T1 mouse breast cancer model, GPX4 degrader-1 (16-66 μmol/kg; intraperitoneal injection; once daily; [10 days]) effectively inhibits tumor growth in a dose-dependent manner. |
| Molecular Weight | 634.16 |
| Formula | C38H36ClN3O4 |
| Cas No. | 3057531-85-5 |
| Smiles | C(CCl)(=O)N1[C@H](C2=C(C=3C(N2)=CC=CC3)C[C@@H]1C(OC)=O)C4=CC=C(C(NCCCC(C5=CC=CC=C5)C6=CC=CC=C6)=O)C=C4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: GPX4 degrader-1 in vivo | GPX4 degrader-1 in vitro | GPX4 degrader-1 formula | GPX4 degrader-1 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.