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DKFZ-633
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Catalog No. T219152 Copy Product Info
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DKFZ-633 is a potent inhibitor of KLK6 and a KLK6-specific probe, exhibiting an IC50 of 250 nM against human KLK6. It selectively covalently labels the active state of KLK6, allowing for the successful pull-down and capture of endogenous active KLK6 from conditioned cell media. DKFZ-633 serves as an important tool for studying the function and regulatory mechanisms of KLK6 in head and neck cancer.
DKFZ-633
Cas No. 2244425-14-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DKFZ-633 is a potent inhibitor of KLK6 and a KLK6-specific probe, exhibiting an IC50 of 250 nM against human KLK6. It selectively covalently labels the active state of KLK6, allowing for the successful pull-down and capture of endogenous active KLK6 from conditioned cell media. DKFZ-633 serves as an important tool for studying the function and regulatory mechanisms of KLK6 in head and neck cancer. |
| In vitro | DKFZ-633 (compound 44) inhibits recombinant triple-mutant human KLK6 at a concentration of 0.25 μM following a 30-minute pre-incubation at room temperature, achieving an IC50 of 0.25 μM. At concentrations of 12-25 μM for 1 hour at room temperature, DKFZ-633 dose-dependently pulls down active endogenous human KLK6 from FaDu cell conditioned medium. When used at 50 μM for 1 hour at room temperature, DKFZ-633 can also pull down active endogenous human KLK6 from conditioned media of various human cancer cell lines, including two glycoform-dependent cell types. |
| Molecular Weight | 440.49 |
| Formula | C26H24N4O3 |
| Cas No. | 2244425-14-5 |
| Smiles | O=C(OCC(=O)NC=1C(=NN(C=2C=CC=CC2)C1C)C)CC=3C=4C=C(C#C)C=CC4NC3C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: DKFZ-633 in vitro | DKFZ-633 formula | DKFZ-633 molecular weight
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