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YS 51

Catalog No. T35280 CAS 213179-96-5

Synonyms: YS-51, YS51

YS 51 is a biochemical.

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YS 51, CAS 213179-96-5

Pack Size	Availability	Price/USD	Quantity
25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

YS 51 is a biochemical.

Synonyms	YS-51, YS51
Molecular Weight	386.289
Formula	C20H20BrNO2
CAS No.	213179-96-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Park EJ, Kim YM, Kim HJ, Jang SY, Oh MH, Lee DH, Chang KC. (S)YS-51, a novel isoquinoline alkaloid, attenuates obesity-associated non-alcoholic fatty liver disease in mice by suppressing lipogenesis, inflammation and coagulation. Eur J Pharmacol. 2016 Oct 5;788:200-209. doi: 10.1016/j.ejphar.2016.06.040. Epub 2016 Jun 23. PubMed PMID: 27343380. 2. Franjoine SE, Bedaiwy MA, AbdelHafez FF, Geng C, Liu JH. Clinical Effectiveness of Modified Laparoscopic Fimbrioplasty for the Treatment of Minimal Endometriosis and Unexplained Infertility. Minim Invasive Surg. 2015;2015:730513. doi: 10.1155/2015/730513. Epub 2015 May 6. PubMed PMID: 26064680; PubMed Central PMCID: PMC4438181. 3. Chaea HJ, Kim HR, Kang YJ, Hyun KC, Kim HJ, Seo HG, Lee JH, Yun-Choi HS, Chang KC. Heme oxygenase-1 induction by (S)-enantiomer of YS-51 (YS-51S), a synthetic isoquinoline alkaloid, inhibits nitric oxide production and nuclear factor-kappaB translocation in ROS 17/2.8 cells activated with inflammatory stimulants. Int Immunopharmacol. 2007 Dec 5;7(12):1559-68. Epub 2007 Aug 14. PubMed PMID: 17920533. 4. Heo JM, Kim HJ, Ha YM, Park MK, Kang YJ, Lee YS, Seo HG, Lee JH, Yun-Choi HS, Chang KC. YS 51, 1-(beta-naphtylmethyl)-6,7-dihydroxy-1,2,3,4,-tetrahydroisoquinoline, protects endothelial cells against hydrogen peroxide-induced injury via carbon monoxide derived from heme oxygenase-1. Biochem Pharmacol. 2007 Nov 1;74(9):1361-70. Epub 2007 Jul 21. PubMed PMID: 17719563.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Molarity Calculator

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Reconstitution Calculation

Molecular Weight Calculator

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Mass of a compound required to prepare a solution of known volume and concentration
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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

YS 51 213179-96-5 YS-51 YS51 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.