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Tripolin A

Catalog No. T8537 CAS 1148118-92-6

Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)

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Tripolin A, CAS 1148118-92-6

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Purity: 98%

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Description	Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)
Targets&IC50	Aurora A:1.5 μM , Aurora A:7 μM
In vitro	Tripolin A, a non-ATP competitive inhibitor.?Tripolin A reduced the localization of pAurora A on spindle microtubules (MTs), affected centrosome integrity, spindle formation and length, as well as MT dynamics in interphase, consistent with Aurora A inhibition by RNAi or other specific inhibitors, such as MLN8054 or MLN8237.?Interestingly, Tripolin A affected the gradient distribution towards the chromosomes, but not the MT binding of HURP (Hepatoma Up-Regulated Protein), a MT-associated protein (MAP) and substrate of the Aurora A kinase.?Therefore Tripolin A reveals a new way of regulating mitotic MT stabilizers through Aurora A phosphorylation.

Molecular Weight	253.25
Formula	C15H11NO3
CAS No.	1148118-92-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Iliana A Kesisova, et al. Tripolin A, a Novel Small-Molecule Inhibitor of Aurora A Kinase, Reveals New Regulation of HURP's Distribution on Microtubules. PLoS One. 2013;8(3):e58485.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tripolin A 1148118-92-6 Cell Cycle/Checkpoint Chromatin/Epigenetic Aurora Kinase Inhibitor (E)-Tripolin A inhibit inhibitor

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