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Teglarinad chloride

Catalog No. T26254 CAS 432037-57-5

Synonyms: GMX 1777 chloride, EB1627, GMX1777, GMX1777 chloride, GMX 1777, GMX-1777 chloride, EB-1627, EB-1627 chloride, EB1627 chloride

Teglarinad chloride (GMX-1777 chloride) is a potent inhibitor of NAMPT, the precursor of GMX1778.Teglarinad chloride has antitumor activity and acts by interfering with DNA repair and inhibiting angiogenesis.

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Teglarinad chloride, CAS 432037-57-5

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1 mg	In stock	$ 210.00

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Purity: 98.09%

Biological Description

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Description

In vivo

In the IM-9 model, small-cell lung cancer (SHP-77) model, and colon carcinoma (HCT-116) model, GMX1777 (75 mg/kg; 24 h intravenous infusion) induces tumor regression[2].For both FaDu and C666-1 tumors in vivo, GMX1777 (50-100 mg/kg/day, intramuscular for 5 days), with or without local tumor radiotherapy, proves to be effective[1].Upon intravenous infusion (25-400 mg/kg; 24 h), GMX1777 is rapidly converted to GMX1778 in the plasma of mice, with a half-life of GMX1777 less than 0.7 h[1].

Synonyms	GMX 1777 chloride, EB1627, GMX1777, GMX1777 chloride, GMX 1777, GMX-1777 chloride, EB-1627, EB-1627 chloride, EB1627 chloride
Molecular Weight	672.6
Formula	C30H43Cl2N5O8
CAS No.	432037-57-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Beauparlant P, et, al. Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777. Anticancer Drugs. 2009 Jun;20(5):346-54. 2. Kato H, et, al. Efficacy of combining GMX1777 with radiation therapy for human head and neck carcinoma. Clin Cancer Res. 2010 Feb 1;16(3):898-911. 3. Olesen UH, Petersen JG, Garten A, Kiess W, Yoshino J, Imai S, Christensen MK, Fristrup P, Thougaard AV, Björkling F, Jensen PB, Nielsen SJ, Sehested M. Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase. BMC Cancer. 2010 Dec 12;10:677. doi: 10.1186/1471-2407-10-677. PubMed PMID: 21144000; PubMed Central PMCID: PMC3019212. 4. Bi TQ, Che XM. Nampt/PBEF/visfatin and cancer. Cancer Biol Ther. 2010 Jul 15;10(2):119-25. doi: 10.4161/cbt.10.2.12581. Epub 2010 Jul 3. Review. PubMed PMID: 20647743.

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Nampt activator-1 LB-60-OF61 OT-82 NAMPT degrader-3 (E)-Daporinad KPT9274 GNE-617 Nampt-IN-5

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Teglarinad chloride 432037-57-5 Metabolism NAMPT GMX 1777 chloride Teglarinad Chloride EB1627 GMX1777 GMX1777 chloride GMX 1777 GMX1777 Chloride GMX-1777 chloride EB-1627 GMX-1777 EB-1627 chloride GMX 1777 Chloride GMX-1777 Chloride EB 1627 EB1627 chloride inhibitor inhibit

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