Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TN1 is a potent inducer of fetal hemoglobin (HbF).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
2 mg | In stock | $ 142.00 | |
5 mg | In stock | $ 239.00 | |
10 mg | In stock | $ 347.00 | |
25 mg | In stock | $ 577.00 | |
50 mg | In stock | $ 823.00 | |
100 mg | In stock | $ 1,090.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 268.00 |
Description | TN1 is a potent inducer of fetal hemoglobin (HbF). |
In vitro | TN1 demonstrates superior efficacy in inducing fetal hemoglobin (HbF) in KU812 and K562 leukemia cell lines compared to hydroxyurea (HU), promoting HbF protein synthesis in a dose-dependent manner. At a concentration of 100 nM, TN1 significantly enhanced γ-globin expression—2.9-fold in KU812 cells and 3.7-fold in K562 cells—surpassing the enhancement achieved with 50-100 μM HU (1.8- and 1.9-fold increases, respectively), making it more effective than the standard SCD treatment. Remarkably, TN1's EC50 value for HbF induction is vastly lower than HU's (HU: EC50=50-100 μM; TN1: EC50=100 nM), highlighting its potency. Additionally, TN1 outperforms other small-molecule HbF inducers, including sodium butyrate and various histone deacetylase (HDAC) inhibitors. Its efficacy extends to increasing γ-globin mRNA transcription by more than fourfold, affecting both transcriptional and protein levels of γ-globin. Within 24 hours of treatment, an increase in both γ-globin mRNA and protein synthesis is observed. TN1 further triggers β-globin mRNA production alongside γ-globin mRNA, akin to the action of hydroxyurea, presenting a promising therapeutic candidate for further exploration. |
Molecular Weight | 509.6 |
Formula | C29H31N7O2 |
CAS No. | 289479-94-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (176.6 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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TN1 289479-94-3 Others TN-1 TN 1 inhibitor inhibit