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TMA-DPH

Catalog No. T19068 CAS 115534-33-3

TMA-DPH is a hydrophobic fluorescent membrane probe (Ex: 355 nm; Em: 430 nm).

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TMA-DPH, CAS 115534-33-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 57.00
5 mg	In stock	Inquiry
25 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 295.00

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Purity: 98.00%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

TMA-DPH is a hydrophobic fluorescent membrane probe (Ex: 355 nm; Em: 430 nm).

In vitro

The TMA-DPH fluorescence lifetime remains constant, 6.2±0.2 ns, below the same critical concentration of 2 μM, but decreases significantly with higher concentrations. This decrease, however, slows down above 5 μM. The TMA-DPH fluorescence anisotropy displays a similar evolution to the fluorescence lifetime. It is first constant, 0.283±0.003, again until 2 μM, and then decreases rapidly to 0.270±0.003 with 5 μM, continuing to fall, but at a lower rate with higher concentrations [2].

Molecular Weight	461.62
Formula	C28H31NO3S
CAS No.	115534-33-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 55 mg/ml (119.15 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Illinger D, et al. The kinetic aspects of intracellular fluorescence labeling with TMA-DPH support the maturation model for endocytosis in L929 cells. J Cell Biol. 1994 May;125(4):783-94. 2. Illinger D, et al. A comparison of the fluorescence properties of TMA-DPH as a probe for plasma membrane and for endocytic membrane. Biochim Biophys Acta. 1995 Oct 4;1239(1):58-66.

Citations

1. Zhao X, Lian X, Xie J, et al.Accumulated cholesterol protects tumours from elevated lipid peroxidation in the microenvironment.Redox Biology.2023: 102678.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TMA-DPH 115534-33-3 Others inhibit Inhibitor TMA DPH TMADPH inhibitor

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