Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB-568849 is a melanin-concentrating hormone receptor 1 antagonist (pKi: 7.7).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,670.00 | |
50 mg | 6-8 weeks | $ 2,180.00 | |
100 mg | 6-8 weeks | $ 2,800.00 |
Description | SB-568849 is a melanin-concentrating hormone receptor 1 antagonist (pKi: 7.7). |
In vitro | SB-568849 is a selective SLC-1 antagonist (pKi: 7.7) as determined in radioligand binding displacement assays. Coincubation of tissue with SB-568849 (1 μM) for 45 min fully inhibits the MCH induced increase in corticotropin-releasing factor (CRF) release to basal levels without causing any effect on its own [2]. |
In vivo | SB-568849 has good receptor affinity and selectivity. SB-568849 displays >30-fold selectivity over a wide range of monoamine receptors and is an antagonist in the FLIPR assay with a pKb of 7.7. SB-568849 retains affinity, demonstrates greater in vivo stability (CLb=16 mL/min/kg), and shows an acceptable brain-blood ratio of 1 [3]. |
Molecular Weight | 500.55 |
Formula | C28H31F3N2O3 |
CAS No. | 395679-53-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SB-568849 395679-53-5 Others SB568849 SB 568849 inhibitor inhibit