Powder: -20°C for 3 years
In solvent: -80°C for 2 years
SA57 is a potent, selective inhibitor of FAAH(IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH).
Description | SA57 is a potent, selective inhibitor of FAAH(IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH). |
Targets&IC50 | Human FAAH:1.9 nM , Mouse ABHD6:850 nM , mouse MAGL:410 nM , Mouse FAAH:3.2 nM , human MAGL:1.4 μM |
In vitro | SA57 exhibits clear time-dependent inhibition of FAAH and MAGL, suggesting a covalent mechanism of inactivation, presumably through carbamylation of the active site serine nucleophiles of these enzymes[1]. |
In vivo | In vivo SA57 (0.01-12.5 mg/kg; intraperitoneal injection; for 2 hours; C57Bl/6 mice) treatment shows distinct dose-responsive activity against brain serine hydrolases (FAAH, MAGL and ABHD6)[1]. |
Molecular Weight | 338.83 |
Formula | C17H23ClN2O3 |
CAS No. | 1346169-63-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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SA57 1346169-63-8 Metabolism Neuroscience FAAH SA-57 Inhibitor inhibitor inhibit