Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S39625, an E-ring camptothecin keto analogue, is a stable, potent, and selective topoisomerase I inhibitor without being substrates of drug efflux transporters. Nanomolar concentrations of S39625 induces intense and persistent histone gamma-H2AX. The chemical stability of the keto analogues and the ability of S39625 to produce high levels of persistent Top1-DNA cleavage complex and its potent antiproliferative activity against human cancer cell lines make S39625 a promising new anticancer drug candidate.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 2,720.00 | |
50 mg | 10-14 weeks | $ 3,580.00 | |
100 mg | 10-14 weeks | $ 4,900.00 |
Description | S39625, an E-ring camptothecin keto analogue, is a stable, potent, and selective topoisomerase I inhibitor without being substrates of drug efflux transporters. Nanomolar concentrations of S39625 induces intense and persistent histone gamma-H2AX. The chemical stability of the keto analogues and the ability of S39625 to produce high levels of persistent Top1-DNA cleavage complex and its potent antiproliferative activity against human cancer cell lines make S39625 a promising new anticancer drug candidate. |
Synonyms | S-39625, S 39625 |
Molecular Weight | 430.45 |
Formula | C25H22N2O5 |
CAS No. | 536711-20-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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S39625 536711-20-3 S-39625 S 39625 inhibitor inhibit