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Ro 12-5637

Catalog No. T34345 CAS 64544-24-7

Synonyms: Ro125637, Ro-12-5637

Ro 12-5637 is a metabolite of moclobemide.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ro 12-5637, CAS 64544-24-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Ro 12-5637 is a metabolite of moclobemide.

Synonyms	Ro125637, Ro-12-5637
Molecular Weight	284.74
Formula	C13H17ClN2O3
CAS No.	64544-24-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Plenis A, Chmielewska A, Konieczna L, Lamparczyk H. A validated high-performance liquid chromatographic method for the determination of moclobemide and its two metabolites in human plasma and application to pharmacokinetic studies. Biomed Chromatogr. 2007 Sep;21(9):958-66. PubMed PMID: 17450597. 2. Pons G, Schoerlin MP, Tam YK, Moran C, Pfefen JP, Francoual C, Pedarriosse AM, Chavinie J, Olive G. Moclobemide excretion in human breast milk. Br J Clin Pharmacol. 1990 Jan;29(1):27-31. PubMed PMID: 2297459; PubMed Central PMCID: PMC1380057. 3. Hoskins JM, Gross AS, Shenfield GM, Rivory LP. High-performance liquid chromatography-electrospray ionization mass spectrometry method for the measurement of moclobemide and two metabolites in plasma. J Chromatogr B Biomed Sci Appl. 2001 Apr 25;754(2):319-26. PubMed PMID: 11339275.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ro 12-5637 64544-24-7 Ro125637 Ro 12 5637 Ro 125637 Ro-12-5637 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.