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Retene

Catalog No. T34298 CAS 483-65-8

Synonyms: NSC 26317, NSC-26317, NSC26317

Retene (NSC-26317) is widely present in recent and ancient sediments, and compounds can be extracted from fir forest soils, humic coals, terrestrial petroleum hydrocarbon source rocks, and deep-sea sediments.Retene is produced by dehydrogenation of pine acids during petrogenesis.

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Retene, CAS 483-65-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 163.00
5 mg	In stock	$ 410.00
10 mg	In stock	$ 597.00
25 mg	In stock	$ 973.00
50 mg	In stock	$ 1,290.00
100 mg	In stock	$ 1,770.00
500 mg	In stock	$ 3,550.00

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Purity: 99.30%

Biological Description

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Storage & Solubility Information

Description	Retene (NSC-26317) is widely present in recent and ancient sediments, and compounds can be extracted from fir forest soils, humic coals, terrestrial petroleum hydrocarbon source rocks, and deep-sea sediments.Retene is produced by dehydrogenation of pine acids during petrogenesis.
Targets&IC50	Whitefish larvae:13.3 microg/L(LC50)
In vitro	In laboratory conditions whitefish larvae were pre-exposed to retene (10, 32 and 100 microg/l), with relevant controls, and irradiated in semi-static tests for 3 h once a day (2 consecutive days) with two UV-B doses (CIE-weighted 2.8 or 5.4 kJ per m(2) per day) or with visible light only. The photoinduced acute LC(50) for retene was 13.3 microg/L. Retene treated fish exhibited signs of behavioral irritation and hypoxia during and after the exposure to UV light. Severe skin damages were detected in larvae exposed simultaneously to retene and UV-B. The structural signs of sunburn could also be seen in UV-B and solvent controls (DMSO) with UV-B. Even at the lowest retene concentration, the number of mucous cells increased significantly in simultaneous chemical and UV-B treatment. We consider the tissue reaction as protective response against UV induced retene toxicity. Further, regarding liver parenchyma, fish exposed to retene with UV-B had lesions, revealing hepatotoxicity.[1]
In vivo	Retene (7-isopropyl-1-methylphenanthrene) is a naturally formed polycyclic aromatic hydrocarbon (PAH) that causes teratogenicity in fish larvae and induction of cytochrome P450 (CYP1A) enzymes. Retene occurs at high concentrations (< or =3,300 microg/g dry wt) in surface sediments contaminated by resin acids from pulp mill effluents. Industrially contaminated sediments collected near a bleached kraft pulp and paper mill discharging to Lake Saimaa, Finland, significantly induced trout liver CYP1A activity, indicating accumulation of arylhydrocarbon receptor (AhR)-active ligands. Induction of CYP1A in fish exposed to sediments spiked with retene or benzo[k]fluoranthene supported this conclusion.[2]

Synonyms	NSC 26317, NSC-26317, NSC26317
Molecular Weight	234.34
Formula	C18H18
CAS No.	483-65-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 18.33 mg/mL (78.23 mM)

References and Literature

1. Häkkinen J, et al. Histopathological responses of newly hatched larvae of whitefish (Coregonus lavaretus s.l.) to UV-B induced toxicity of retene. Aquat Toxicol. 2003;63(2):159-171. 2. Oikari A, et al. Bioavailability to juvenile rainbow trout (Oncorynchus mykiss) of retene and other mixed-function oxygenase-active compounds from sediments. Environ Toxicol Chem. 2002;21(1):121-128. 3. Maria VL, et al. Anguilla anguilla L. liver EROD induction and genotoxic responses after retene exposure. Ecotoxicol Environ Saf. 2005;61(2):230-238. 4. Geier MC, et al. Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish. Toxicol Appl Pharmacol. 2018;41(18)30121-30122. 5. Sun H, et al. Direct determination of surfactant effects on the uptake of gaseous parent and alkylated PAHs by crop leaf surfaces. Ecotoxicol Environ Saf. 2018;154:206-213. 6. Bandowe BAM, et al. A 150-year record of polycyclic aromatic compound (PAC) deposition from high Andean Cajas National Park, southern Ecuador. Sci Total Environ. 2018;621:1652-1663. 7. De Oliveira Alves N, et al. Biomass burning in the Amazon region causes DNA damage and cell death in human lung cells. Sci Rep. 2017;7(1):10937.

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Keywords

Retene 483-65-8 NSC 26317 NSC-26317 NSC26317 inhibitor inhibit

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