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Oxamflatin

Catalog No. T16415 CAS 151720-43-3

Synonyms: Metacept-3

Oxamflatin is an effective inhibitor of <a href="/target/HDAC" style="display: inline; color: #c13a36">HDAC</a> (IC50: 15.7 nM).

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Oxamflatin, CAS 151720-43-3

Pack Size	Availability	Price/USD
5 mg	10-12 weeks	$ 1,170.00
50 mg	10-12 weeks	$ 2,380.00
100 mg	10-12 weeks	$ 3,100.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Oxamflatin is an effective inhibitor of HDAC (IC50: 15.7 nM).
Targets&IC50	HDAC:15.7 nM
In vitro	Oxamflatin is able to significantly inhibit DNA synthesis and cell proliferation. Oxamflatin can induce E-cadherin expression and also reduce cell viability in the MKN-45 cell line. Oxamflatin causes transcriptional activation of junD and morphological reversion in various NIH3T3-derived transformed cell lines. Oxamflatin induces an elongated cell shape with filamentous protrusions as well as the arrest of the cell cycle at the G1 phase in HeLa cells. Oxamflatin displays antiproliferative activity against various mouse and human tumor cell lines with drastic changes in the cell morphology. Oxamflatin greatly increases the transcriptional activity of the CMV promoter in a dose-dependent manner and inhibits intracellular HDAC activity[1][2][3].
In vivo	The ILS of the mice treated with Oxamflatin at the dose of 50 mg/kg is calculated to be more than 67% and one mouse survived over 60 days after tumor inoculation. Injection of Oxamflatin, six times at the dose of 20 mg/kg, shows a significant increase in the days of survival (38% of ILS) [1].

Synonyms	Metacept-3
Molecular Weight	342.37
Formula	C17H14N2O4S
CAS No.	151720-43-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (365.10 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kim YB, et al. Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase. Oncogene. 1999 Apr 15;18(15):2461-70. 2. Wang YL, et al. HDAC Inhibitor Oxamflatin Induces Morphological Changes and has Strong Cytostatic Effects in Ovarian Cancer Cell Lines. Curr Mol Med. 2016;16(3):232-42. 3. Faghihloo E, et al. The effect of oxamflatin on the E-cadherin expression in gastric cancer cell line. Cancer Gene Ther. 2016 Nov;23(11):396-399.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Oxamflatin 151720-43-3 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Metacept-3 Inhibitor inhibitor inhibit

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