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Omtriptolide

Catalog No. T16390 CAS 195883-06-8

Omtriptolide, triptolide purified from the Chinese herb, is a water-soluble derivative prodrug.

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Omtriptolide, CAS 195883-06-8

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Omtriptolide, triptolide purified from the Chinese herb, is a water-soluble derivative prodrug.
In vitro	Triptolide is a traditional Chinese medicine. It also has anti-inflammatory, antiproliferative, and proapoptotic properties[1].
In vivo	Omtriptolide effectively reduces fibrosis in groups treated with bleomycin, either when administered concurrently or five days post-treatment. It significantly diminishes in vivo expansion of both CD4+Vbeta3+ and CD8+Vbeta3+ T cells (alloreactive T cells in this context) in the spleen by 64.09% and 34.02%, respectively, particularly during the logarithmic expansion phase (day 3 post-transplantation). Additionally, it notably decreases the population of myofibroblasts in the bleomycin-treated cohorts. In a cisplatin-induced acute kidney injury (AKI) mouse model, Omtriptolide substantially lowers blood urea nitrogen (BUN), serum creatinine levels, and acute tubular necrosis (ATN) scores, while slightly increasing the tubular apoptosis score, indicating a protective role against AKI. This protection correlates with a reduction in p-ERK activity, operating independently of MKP-1 and pro-inflammatory cytokines[1]. Furthermore, Omtriptolide alleviates airway obliteration and curtails the aggregation of inflammatory cells, suggesting potential preventive or therapeutic applications for obliterative airway diseases post-lung transplantation, as demonstrated in a mouse heterotopic tracheal allograft model[2][3][4].

Molecular Weight	460.479
Formula	C24H28O9
CAS No.	195883-06-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kim HJ, et al. The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury. J Pharmacol Exp Ther. 2014 Jun;349(3):518-25. 2. Leonard CT, et al. PG490-88, a derivative of triptolide, attenuates obliterative airway disease in a mouse heterotopic tracheal allograft model. J Heart Lung Transplant. 2002 Dec;21(12):1314-8. 3. Krishna G, et al. PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis. Am J Pathol. 2001 Mar;158(3):997-1004. 4. Chen BJ, et al. Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion. Transplantation. 2000 Nov 27;70(10):1442-7.

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Keywords

Omtriptolide 195883-06-8 MAPK ERK inhibitor inhibit

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