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Olopatadine

Catalog No. T21462   CAS 113806-05-6
Synonyms: Opatanol, Patanol, KW-4943A, KW-4679

Olopatadine, an antihistamine, as well as anticholinergic and mast cell stabilizer, is used for the treatment of itching associated with allergic conjunctivitis (eye allergies). There is also a potential for Olopatadine to treat steroid rebound (red skin syndrome).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Olopatadine Chemical Structure
Olopatadine, CAS 113806-05-6
Pack Size Availability Price/USD Quantity
25 mg Inquiry $ 1,520.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Olopatadine, an antihistamine, as well as anticholinergic and mast cell stabilizer, is used for the treatment of itching associated with allergic conjunctivitis (eye allergies). There is also a potential for Olopatadine to treat steroid rebound (red skin syndrome).
Synonyms Opatanol, Patanol, KW-4943A, KW-4679
Molecular Weight 337.41
Formula C21H23NO3
CAS No. 113806-05-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: Soluble

TargetMolReferences and Literature

1. Olopatadine for the Treatment of Allergic Conjunctivitis: A Review of the Clinical Efficacy, Safety, and Cost-Effectiveness [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016 Mar 17. Available from http://www.ncbi.nlm.nih.gov/books/NBK355639/ PubMed PMID: 27077162. 2. Nickels AS, Dimov V, Wolf R. Pharmacokinetic evaluation of olopatadine for the treatment of allergic rhinitis and conjunctivitis. Expert Opin Drug Metab Toxicol. 2011 Dec;7(12):1593-9. doi: 10.1517/17425255.2011.630389. Epub 2011 Oct 28. Review. PubMed PMID: 22032416. 3. Roland PS, Ryan MW, Wall GM. Olopatadine nasal spray for the treatment of seasonal allergic rhinitis in patients aged 6 years and older. Expert Opin Pharmacother. 2010 Jun;11(9):1559-67. doi: 10.1517/14656566.2010.485609. Review. PubMed PMID: 20482305. 4. Leonardi A, Quintieri L. Olopatadine: a drug for allergic conjunctivitis targeting the mast cell. Expert Opin Pharmacother. 2010 Apr;11(6):969-81. doi: 10.1517/14656561003694643. Review. PubMed PMID: 20307221. 5. Ge S, Wang X, Hou Y, et al. Repositioning of histamine H1 receptor antagonist: Doxepin inhibits viropexis of SARS-CoV-2 Spike pseudovirus by blocking ACE2[J]. European Journal of Pharmacology. 2021: 173897.

TargetMolCitations

1. Yu, W., et al. AMPK-SIRT1 Pathway Modulates The Apoptosis, Proliferation and Migration of AR42J Cells By Regulating p53 and NF-κB. European Journal of Pharmacology. 2021 2. Ge S, Wang X, Hou Y, et al. Repositioning of histamine H1 receptor antagonist: Doxepin inhibits viropexis of SARS-CoV-2 Spike pseudovirus by blocking ACE2. European Journal of Pharmacology. 2021 Apr 5;896:173897. doi: 10.1016/j.ejphar.2021.173897. Epub 2021 Jan 23.

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Keywords

Olopatadine 113806-05-6 Opatanol Patanol KW 4679 KW4679 KW-4943A KW-4679 inhibitor inhibit

 

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