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Nuvenzepine

Catalog No. T16362 CAS 96487-37-5

Nuvenzepine is an antagonist of mAChR. It has the potential for gastrospasm treatment.

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Nuvenzepine, CAS 96487-37-5

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Nuvenzepine is an antagonist of mAChR. It has the potential for gastrospasm treatment.
In vitro	Nuvenzepine demonstrates nearly equal potency to pirenzepine in competitively inhibiting bethanechol-induced gallbladder contractions and exhibits a four-fold greater potency in preventing vagal-stimulated tracheal constrictions. Additionally, it has a four-fold higher affinity than pirenzepine in competitively antagonizing acetylcholine-induced contractions in both isolated ileal musculature and longitudinal ileum dispersed cells [1].
In vivo	Nuvenzepine, distinct from pirenzepine, actively moderates colonic motility and, when administered intraduodenally in anaesthetized cats, exhibits a prolonged, dose-dependent suppression of neostigmine-induced intestinal movement. This compound significantly reduces gastric acid secretion and intestinal hypermotility in rats while manifesting minimal atropine-like side effects. It is characterized by slow oral absorption, with an absolute bioavailability of 30 to 40%, slow elimination, negligible accumulation in the body, and minimal metabolism. Notably, Nuvenzepine's efficacy in inhibiting ileal motor activity is tenfold that of pirenzepine and demonstrates a 25-30 times higher potency in suppressing pentagastrin-stimulated gastric acid secretion in conscious cats, indicating its significant therapeutic potential.

Molecular Weight	336.39
Formula	C19H20N4O2
CAS No.	96487-37-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Barocelli E, et al. Functional comparison between nuvenzepine and pirenzepine on different guinea pig isolated smooth muscle preparations. Pharmacol Res. 1994 Aug-Sep;30(2):161-70. 2. Barocelli E, et al. Gastrointestinal activities of a new pirenzepine-analog, nuvenzepine, in the cat. Farmaco. 1990 Oct;45(10):1089-99. 3. Caselli G, et al. Determination of nuvenzepine in human plasma by a sensitive [3H]pirenzepine radioreceptor binding assay. J Pharm Sci. 1991 Feb;80(2):173-7.

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Keywords

Nuvenzepine 96487-37-5 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR inhibitor inhibit

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