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Neocuproine

Catalog No. T33631 CAS 484-11-7

Synonyms: Neocuproin

Neocuproine is a copper(I) chelator that enhances the purinergic component of vasoconstriction induced by electric field stimulation, and is often used as a ligand reagent and copper ion detector.Neocuproine forms stable complexes with copper ions and can play a catalytic role in certain chemical reactions and analytical methods.Neocuproine acts as a redox-active on the iron and cobalt ligand platform for protection against oxidative damage in NSC34 cells.

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Neocuproine, CAS 484-11-7

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Neocuproine is a copper(I) chelator that enhances the purinergic component of vasoconstriction induced by electric field stimulation, and is often used as a ligand reagent and copper ion detector.Neocuproine forms stable complexes with copper ions and can play a catalytic role in certain chemical reactions and analytical methods.Neocuproine acts as a redox-active on the iron and cobalt ligand platform for protection against oxidative damage in NSC34 cells.
In vitro	Neocuproine (100 lM) generally inhibits the production of inflammatory mediators.[2] Neocuproine treatment reduced IFN-γ, MCP-1, MCP-3, and VEGF-A levels. The production of KC/GRO was downregulated by neocuproine deficiency.[2] Neocuproine, but not ATP7A deficiency, reduced the production of FGF-9, IL-1α, IL-12p70, IL-2, IL-3, IL-4, IL-6, MIP-1β, MIP-2, RANTES, and TNFα.[2]
In vivo	Neocuproine (100 microM) significantly suppressed the amplitude and frequency of the spontaneous contractions in the ovariectomized non-pregnant rat uterus while this agent facilitated the frequency of the spontaneous or oxytocin-induced contractions in the pregnant rat and human uterus without altering the amplitude of these contractions.[3] Neocuproine (200 microM) could enhance the amplitude of the contractions in the pregnant uterus. These effects were blocked by a purinergic receptor antagonist, suramin (100 microM) and did not occur following the administration of neocuproine-copper(I) complex or copper(II) chelator cuprizone. alpha, beta-methylene ATP increased the amplitude and frequency of contractions in the pregnant uterus, but not affected the contractions in the ovariectomized non-pregnant rat uterus, and neocuproine potentiated this facilitation effect.[3]

Synonyms	Neocuproin
Molecular Weight	208.26
Formula	C14H12N2
CAS No.	484-11-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45.0 mg/mL (216.1 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Castro PA, et al. Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons. Front Aging Neurosci. 2014 Dec 3;6:319. 2. Patel OV, et al. Production of LPS-induced inflammatory mediators in murine peritoneal macrophages: neocuproine as a broad inhibitor and ATP7A as a selective regulator. Biometals. 2013 Jun;26(3):415-25. 3. Kumcu EK, et al. Differential effect of neocuproine, a copper(I) chelator, on contractile activity in isolated ovariectomized non-pregnant rat, pregnant rat and pregnant human uterus. Eur J Pharmacol. 2009 Mar 1;605(1-3):158-63. 4. Soares SAR, et al. Comparison of Spectrophotometric Methods for the Determination of Copper in Sugar Cane Spirit. J AOAC Int. 2018 May 1;101(3):876-882.

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Keywords

Neocuproine 484-11-7 Neocuproin inhibitor inhibit

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