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Lintitript

Lintitript
Lintitript (SR 27897) is a selective CCK1 antagonist with an EC50 of 6 nM for CCK1 and 200 nM for CCK2, and a Ki value of 0.2 nM for CCK1.
Catalog No. T15759Cas No. 136381-85-6
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Purity:98.48%
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Lintitript

Catalog No. T15759Cas No. 136381-85-6

Lintitript (SR 27897) is a selective CCK1 antagonist with an EC50 of 6 nM for CCK1 and 200 nM for CCK2, and a Ki value of 0.2 nM for CCK1.
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Pack SizePriceAvailabilityQuantity
1 mg$117In Stock
2 mg$160In Stock
5 mg$247In Stock
10 mg$370In Stock
25 mg$591In Stock
50 mg$798In Stock
100 mg$1,070In Stock
1 mL x 10 mM (in DMSO)$273In Stock
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Product Introduction

Bioactivity
Description
Lintitript (SR 27897) is a selective CCK1 antagonist with an EC50 of 6 nM for CCK1 and 200 nM for CCK2, and a Ki value of 0.2 nM for CCK1.
Targets&IC50
CCK1 receptor:(ki)0.2 nM, CCK1:(EC50)6 nM
In vitro
Lintitript inhibited the CCK 2 site in guinea pig cortex with an IC2 of 479 nM. lintitript (0.5 nM) increased the dissociation constant of CCK on CCKA receptors with Kds between 1.8 and 7.2 nM without altering the maximum number of receptors. lintitript antagonized CCK-stimulated isolated rat pancreatic follicles in (amylase release and CCK-induced gallbladder contraction in guinea pigs with pA2s of 7.50 and 9.57). lintitript inhibited the binding of [125I]CCK to the rat pancreatic CCK1 receptor site with IC50 of 0.58 nM in a concentration-dependent manner[1].
In vivo
Lintitript (1 mg/kg, i.v.) completely reversed CCK-induced amylase secretion. lintitript inhibited CCK-induced gastric and gallbladder emptying in mice with ED50s of 3 μg/kg and 72 μg/kg. lintitript (p.o.) was active in the gallbladder emptying protocol of egg yolk-induced endogenous CCK release, with an ED50 of 27 μg/kg [1].
AliasSR 27897
Chemical Properties
Molecular Weight411.86
FormulaC20H14ClN3O3S
Cas No.136381-85-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90 mg/mL (218.5 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4280 mL12.1400 mL24.2801 mL121.4005 mL
5 mM0.4856 mL2.4280 mL4.8560 mL24.2801 mL
10 mM0.2428 mL1.2140 mL2.4280 mL12.1400 mL
20 mM0.1214 mL0.6070 mL1.2140 mL6.0700 mL
50 mM0.0486 mL0.2428 mL0.4856 mL2.4280 mL
100 mM0.0243 mL0.1214 mL0.2428 mL1.2140 mL

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