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Description | KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively). |
In vivo | Evaluating the inhibition of LMP2, and antitargets LMP7 and β5, in mouse tissues reveals that KZR-504 is both selective and potent in vivo. In all tissues tested except the brain, it has >50% target inhibition achieved at >1 mg/kg [1]. |
Molecular Weight | 413.42 |
Formula | C21H23N3O6 |
Cas No. | 1629052-78-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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