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KZR-504

Catalog No. T15678 CAS 1629052-78-3

KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).

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KZR-504, CAS 1629052-78-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).
Targets&IC50	LMP2:51 nM, LMP7:4.274 μM
In vivo	Evaluating the inhibition of LMP2, and antitargets LMP7 and β5, in mouse tissues reveals that KZR-504 is both selective and potent in vivo. In all tissues tested except the brain, it has >50% target inhibition achieved at >1 mg/kg [1].

Molecular Weight	413.42
Formula	C21H23N3O6
CAS No.	1629052-78-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Johnson HWB, et al. Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit. ACS Med Chem Lett. 2017 Mar 9;8(4):413-417.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KZR-504 1629052-78-3 Proteases/Proteasome Ubiquitination Proteasome KZR 504 KZR504 Inhibitor inhibitor inhibit

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