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KZR-504

Catalog No. T15678   CAS 1629052-78-3

KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).

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KZR-504 Chemical Structure
KZR-504, CAS 1629052-78-3
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Biological Description
Chemical Properties
Storage & Solubility Information
Description KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).
Targets&IC50 LMP2:51 nM, LMP7:4.274 μM
In vivo Evaluating the inhibition of LMP2, and antitargets LMP7 and β5, in mouse tissues reveals that KZR-504 is both selective and potent in vivo. In all tissues tested except the brain, it has >50% target inhibition achieved at >1 mg/kg [1].
Molecular Weight 413.42
Formula C21H23N3O6
CAS No. 1629052-78-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Johnson HWB, et al. Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit. ACS Med Chem Lett. 2017 Mar 9;8(4):413-417.

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Keywords

KZR-504 1629052-78-3 Proteases/Proteasome Ubiquitination Proteasome KZR504 KZR 504 inhibitor inhibit

 

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