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KMUP-3

Catalog No. T32405 CAS 421556-16-3

Synonyms: KMUP 3, KMUP3

KMUP-3 is an enhancer of cGMP activity, and acts as an aortic smooth muscle relaxant.

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KMUP-3, CAS 421556-16-3

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

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Description

KMUP-3 is an enhancer of cGMP activity, and acts as an aortic smooth muscle relaxant.

Synonyms	KMUP 3, KMUP3
Molecular Weight	413.43
Formula	C19H23N7O4
CAS No.	421556-16-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Liu CP, Yeh JL, Liou SF, Wu BN, Chen IJ. Phosphodiesterase inhibitor KMUP-3 displays cardioprotection via protein kinase G and increases cardiac output via G-protein-coupled receptor agonist activity and Ca(2+) sensitization. Kaohsiung J Med Sci. 2016 Feb;32(2):55-67. doi: 10.1016/j.kjms.2016.01.005. Epub 2016 Feb 24. PubMed PMID: 26944323. 2. Winardi W, Wang CJ, Lin CL, Wu SC, Tsai HP, Kuo YH, Lee MY, Chen IJ, Kwan AL. Attenuation of cerebral vasospasm following experimental subarachnoid hemorrhage by the bronchodilator KMUP-3. Acta Neurochir Suppl. 2013;115:239-46. doi: 10.1007/978-3-7091-1192-5_43. PubMed PMID: 22890675. 3. Liu CP, Yeh JL, Wu BN, Chai CY, Chen IJ, Lai WT. KMUP-3 attenuates ventricular remodelling after myocardial infarction through eNOS enhancement and restoration of MMP-9/TIMP-1 balance. Br J Pharmacol. 2011 Jan;162(1):126-35. doi: 10.1111/j.1476-5381.2010.01024.x. PubMed PMID: 20840538; PubMed Central PMCID: PMC3012411. 4. Wu BN, Chen CW, Liou SF, Yeh JL, Chung HH, Chen IJ. Inhibition of proinflammatory tumor necrosis factor-{alpha}-induced inducible nitric-oxide synthase by xanthine-based 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in rat trachea: The involvement of soluble guanylate cyclase and protein kinase G. Mol Pharmacol. 2006 Sep;70(3):977-85. Epub 2006 Jun 5. PubMed PMID: 16754782.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KMUP-3 421556-16-3 KMUP 3 KMUP3 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.