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KIRA-7

Catalog No. T15664   CAS 1937235-76-1

KIRA-7 is an imidazopyrazine compound. KIRA-7 has an anti-fibrotic effect. KIRA-7 binds the IRE1α kinase (IC50: 110 nM) to allosterically inhibit its RNase activity.

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KIRA-7 Chemical Structure
KIRA-7, CAS 1937235-76-1
Pack Size Availability Price/USD Quantity
1 mg 5 days $ 141.00
50 mg 6-8 weeks $ 1,780.00
100 mg 6-8 weeks $ 2,800.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description KIRA-7 is an imidazopyrazine compound. KIRA-7 has an anti-fibrotic effect. KIRA-7 binds the IRE1α kinase (IC50: 110 nM) to allosterically inhibit its RNase activity.
Targets&IC50 IRE1α kinase:110 nM
In vitro In the alveolar epithelial cell line MLE12, KIRA-7 inhibits XBP1 splicing [1].
In vivo After Bleomycin exposure, mRNA levels of BiP and CHOP are significantly elevated, and treatment of Bleomycin-exposed mice with KIRA-7 decreased these levels. KIRA-7 (5 mg/kg; intraperitoneal injection; daily for 14 days; C57BL6 mice) treatment causes decreased spliced XBP1 and ATF4, compared to bleomycin exposed mice treated with vehicle. mRNA levels of collagen 1A1 and fibronectin are both significantly decreased by KIRA-7 treatment [1].
Molecular Weight 466.51
Formula C27H23FN6O
CAS No. 1937235-76-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

TargetMolReferences and Literature

1. Thamsen M, et al. Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung. PLoS One. 2019 Jan 9;14(1):e0209824.

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Keywords

KIRA-7 1937235-76-1 Others KIRA 7 KIRA7 inhibitor inhibit

 

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