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KIRA-7

Catalog No. T15664 CAS 1937235-76-1

KIRA-7 is an imidazopyrazine compound. KIRA-7 has an anti-fibrotic effect. KIRA-7 binds the IRE1α kinase (IC50: 110 nM) to allosterically inhibit its RNase activity.

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KIRA-7, CAS 1937235-76-1

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,370.00
50 mg	6-8 weeks	$ 1,780.00
100 mg	6-8 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

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Description	KIRA-7 is an imidazopyrazine compound. KIRA-7 has an anti-fibrotic effect. KIRA-7 binds the IRE1α kinase (IC50: 110 nM) to allosterically inhibit its RNase activity.
Targets&IC50	IRE1α kinase:110 nM
In vitro	In the alveolar epithelial cell line MLE12, KIRA-7 inhibits XBP1 splicing [1].
In vivo	After Bleomycin exposure, mRNA levels of BiP and CHOP are significantly elevated, and treatment of Bleomycin-exposed mice with KIRA-7 decreased these levels. KIRA-7 (5 mg/kg; intraperitoneal injection; daily for 14 days; C57BL6 mice) treatment causes decreased spliced XBP1 and ATF4, compared to bleomycin exposed mice treated with vehicle. mRNA levels of collagen 1A1 and fibronectin are both significantly decreased by KIRA-7 treatment [1].

Molecular Weight	466.51
Formula	C27H23FN6O
CAS No.	1937235-76-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Thamsen M, et al. Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung. PLoS One. 2019 Jan 9;14(1):e0209824.

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Keywords

KIRA-7 1937235-76-1 Others KIRA 7 KIRA7 inhibitor inhibit

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