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KCC009

Name: KCC009
Brand: TargetMol
SKU: T27717
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27717Cas No. 744198-19-4

Alias KCC-009, KCC 009

KCC009 is a competitive transglutaminase 2 (TG2) inhibitor (IC50 = 20 μM). It sensitizes cancer cells to chemotherapy by blocking TG2-mediated survival signaling in glioblastoma research.

KCC009

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Purity: 98.68%

Catalog No. T27717Alias KCC-009, KCC 009Cas No. 744198-19-4

KCC009 is a competitive transglutaminase 2 (TG2) inhibitor (IC50 = 20 μM). It sensitizes cancer cells to chemotherapy by blocking TG2-mediated survival signaling in glioblastoma research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$84	-	In Stock
5 mg	$198	-	In Stock
10 mg	$313	-	In Stock
25 mg	$619	-	In Stock
50 mg	$993	-	In Stock
1 mL x 10 mM (in DMSO)	$215	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.68%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	KCC009 is a competitive transglutaminase 2 (TG2) inhibitor (IC50 = 20 μM). It sensitizes cancer cells to chemotherapy by blocking TG2-mediated survival signaling in glioblastoma research.
In vitro	KCC009 (3.91 uM) induces radiosensitization in H1299 lung cancer cells by inhibiting TG2-mediated protein cross-linking [1].
In vivo	KCC009 disrupts fibronectin assembly in mouse glioblastoma models, enhancing drug penetration and prolonging survival [2].
Synonyms	KCC-009, KCC 009

Chemical Properties

Molecular Weight	476.32
Formula	C₂₁H₂₂BrN₃O₅
Cas No.	744198-19-4
Smiles	[C@H](CC1=CC=C(O)C=C1)(C(NCC2ON=C(Br)C2)=O)NC(OCC3=CC=CC=C3)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (419.89 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0994 mL	10.4971 mL	20.9943 mL	104.9714 mL
5 mM	0.4199 mL	2.0994 mL	4.1989 mL	20.9943 mL
10 mM	0.2099 mL	1.0497 mL	2.0994 mL	10.4971 mL
20 mM	0.1050 mL	0.5249 mL	1.0497 mL	5.2486 mL
50 mM	0.0420 mL	0.2099 mL	0.4199 mL	2.0994 mL
100 mM	0.0210 mL	0.1050 mL	0.2099 mL	1.0497 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc