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JI051

Catalog No. T11718 CAS 2234281-75-3

Synonyms: JI-051

JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) to induce cell cycle arrest by inhibiting the transcription of the Notch downstream effector gene, Hes1, and inhibits the proliferation of HEK293 cells and pancreatic cancer cells.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

JI051, CAS 2234281-75-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 58.00
2 mg	5 days	$ 82.00
5 mg	In stock	$ 372.00
1 mL * 10 mM (in DMSO)	5 days	$ 397.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) to induce cell cycle arrest by inhibiting the transcription of the Notch downstream effector gene, Hes1, and inhibits the proliferation of HEK293 cells and pancreatic cancer cells.
Targets&IC50	Cell proliferation:0.3 μM (EC50, HEK293 cell)
In vitro	JI051 (0.1-10 µM, 24 hours) significantly inhibits proliferation of HEK293 cells, exhibiting an EC50 of 0.3 μM, and induces G2/M cell-cycle arrest[1].

Synonyms	JI-051
Molecular Weight	364.44
Formula	C22H24N2O3
CAS No.	2234281-75-3

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (274.39 mM), Sonication is recommended.

References and Literature

1. Perron A, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JI051 2234281-75-3 Neuroscience Proteases/Proteasome Stem Cells Gamma-secretase JI-051 JI 051 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.