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GPR84 antagonist 8

Catalog No. T11462 CAS 1445846-30-9

<a href="/target/GPR" style="display: inline; color: #c13a36">GPR</a>84 antagonist 8 is a selective <a href="/target/GPR" style="display: inline; color: #c13a36">GPR</a>84 antagonist.

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GPR84 antagonist 8, CAS 1445846-30-9

Pack Size	Availability	Price/USD
5 mg	Synthesizing, 6-8 weeks	$ 1,070.00
50 mg	Synthesizing, 6-8 weeks	$ 2,180.00
100 mg	Synthesizing, 6-8 weeks	$ 2,800.00

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Purity: 98%

Biological Description

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Description

GPR84 antagonist 8 is a selective GPR84 antagonist.

In vitro

GPR84 antagonist 8 effectively inhibits the action of 6-OAU in decreasing cAMP production in GPR84-CHO cells. To test GPR84 antagonist 8's inhibition of the pro-inflammatory effects of GPR84 activation in macrophages, LPS pre-treated BMDMs are incubated with 10?μM GPR84 antagonist 8 for 30?min before adding 1?μM 6-OAU. Protein analysis by Western Blot shows that the GPR84 antagonist 8 partially blocks the phosphorylation of AKT and ERK induced by 6-OAU.GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been described predominantly in immune cells.?To test the hypothesis that blocking the activation of GPR84 can be a potential anti-inflammatory strategy in different inflammatory diseases, GPR84 antagonist 8 is used.?The potency and specificity of GPR84 antagonist 8 is assessed tusing GPR84-CHO cells in the cAMP assay.

Molecular Weight	421.45
Formula	C23H23N3O5
CAS No.	1445846-30-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 5 mg/mL (11.86 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Recio C, et al. Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages. Front Immunol. 2018 Jun 20;9:1419.

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Keywords

GPR84 antagonist 8 1445846-30-9 GPCR/G Protein Endocrinology/Hormones GPR GPR-84 antagonist 8 Inhibitor inhibitor inhibit

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