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GPR84 antagonist 8
😃Good
Catalog No. T11462Cas No. 1445846-30-9
GPR84 antagonist 8 is a selective GPR84 antagonist.
GPR84 antagonist 8
😃Good
Catalog No. T11462Cas No. 1445846-30-9
GPR84 antagonist 8 is a selective GPR84 antagonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $4,528 | 6-8 weeks | |
| 50 mg | $6,339 | 6-8 weeks | |
| 100 mg | $8,879 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GPR84 antagonist 8 is a selective GPR84 antagonist. |
| In vitro | GPR84 antagonist 8 is shown to effectively counteract the decrease in cAMP production triggered by 6-OAU in GPR84-CHO cells, hinting at its ability to inhibit GPR84's action. To examine its potential in mitigating GPR84 activation's pro-inflammatory effects in macrophages, bone marrow-derived macrophages (BMDMs) pretreated with LPS were exposed to 10μM of the antagonist for 30 minutes prior to the introduction of 1μM 6-OAU. Western Blot analysis indicated that GPR84 antagonist 8 notably reduces the phosphorylation of AKT and ERK prompted by 6-OAU, showcasing its partial blockade. Given GPR84's prominence in immune cells as part of the G protein-coupled receptor family associated with metabolism, utilizing GPR84 antagonist 8 emerges as a promising anti-inflammatory approach against various inflammatory diseases. The antagonist's effectiveness and specificity were further validated through cAMP assay trials conducted on GPR84-CHO cells. |
| Molecular Weight | 421.45 |
| Formula | C23H23N3O5 |
| Cas No. | 1445846-30-9 |
| Relative Density. | 1.38 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (11.86 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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