Powder: -20°C for 3 years
In solvent: -80°C for 2 years
<a href="/target/GPR" style="display: inline; color: #c13a36">GPR</a>84 antagonist 8 is a selective <a href="/target/GPR" style="display: inline; color: #c13a36">GPR</a>84 antagonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Synthesizing, 6-8 weeks | $ 1,070.00 | |
50 mg | Synthesizing, 6-8 weeks | $ 2,180.00 | |
100 mg | Synthesizing, 6-8 weeks | $ 2,800.00 |
Description | GPR84 antagonist 8 is a selective GPR84 antagonist. |
In vitro | GPR84 antagonist 8 effectively inhibits the action of 6-OAU in decreasing cAMP production in GPR84-CHO cells. To test GPR84 antagonist 8's inhibition of the pro-inflammatory effects of GPR84 activation in macrophages, LPS pre-treated BMDMs are incubated with 10?μM GPR84 antagonist 8 for 30?min before adding 1?μM 6-OAU. Protein analysis by Western Blot shows that the GPR84 antagonist 8 partially blocks the phosphorylation of AKT and ERK induced by 6-OAU.GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been described predominantly in immune cells.?To test the hypothesis that blocking the activation of GPR84 can be a potential anti-inflammatory strategy in different inflammatory diseases, GPR84 antagonist 8 is used.?The potency and specificity of GPR84 antagonist 8 is assessed tusing GPR84-CHO cells in the cAMP assay. |
Molecular Weight | 421.45 |
Formula | C23H23N3O5 |
CAS No. | 1445846-30-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 5 mg/mL (11.86 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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GPR84 antagonist 8 1445846-30-9 GPCR/G Protein Endocrinology/Hormones GPR GPR-84 antagonist 8 Inhibitor inhibitor inhibit