Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DO34 is a highly potent and centrally active inhibitor of diacylglycerol lipase (IC50: 6 nM for DAGLα conversion of SAG to 2-AG).
Description | DO34 is a highly potent and centrally active inhibitor of diacylglycerol lipase (IC50: 6 nM for DAGLα conversion of SAG to 2-AG). |
Targets&IC50 | DAGLα:6 nM, DAGLβ:3-8 nM |
In vitro | DO34 also is a potent inhibitor of DAGLβ with IC50 of 3-8 nM [1]. |
In vivo | DO34 could block the tonic CB1 activation. DO34 prevents fasting-induced refeeding of mice, this is typical cannabinoid CB1-receptor-mediated behavior. DO34 decreases brain 2-AG levels in a dose- and time-dependent manner [2]. AM251 obviously increases basal PF-EPSCs in MAGL-TKO mice. The effect of AM251 is blocked by the DAGL inhibitor DO34 [3]. |
Molecular Weight | 531.53 |
Formula | C26H28F3N5O4 |
CAS No. | 1848233-58-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (188.14 mM)
You can also refer to dose conversion for different animals. More
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DO34 1848233-58-8 Others DO 34 DO-34 inhibitor inhibit