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BGB-102

Catalog No. T10531 CAS 807640-87-5

Synonyms: JNJ-26483327

BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3, which may be useful in the study of macular degeneration and diseases associated with genetic disorders and malformations.

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BGB-102, CAS 807640-87-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 373.00
5 mg	In stock	$ 893.00
10 mg	In stock	$ 1,220.00
25 mg	In stock	$ 1,820.00
50 mg	In stock	$ 2,380.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3, which may be useful in the study of macular degeneration and diseases associated with genetic disorders and malformations.
Targets&IC50	18 nM:HER4, EGFR:9.6 nM, HER2:18 nM
In vitro	Herceptin was combined with pan HER inhibitor BGB-102 ( 1,5 or 10 μM ) to treat SKBR3 cells for 1 hour. The results showed that herceptin combined with BGB-102 could terminate the PKB feedback loop and had a synergistic effect in inhibiting the growth of xenograft tumors[1].
In vivo	BT474 xenografts were treated with vehicle control, BGB-102 (75 mg/kg, orally twice daily), Herceptin (10 mg/kg；ip), or combination therapy of BGB-102 and Herceptin for 21 days, followed by observation for 120 days. The results indicated that the combination therapy of Herceptin with BGB-102 delayed the growth of BT474 xenograft tumors[1].

Synonyms	JNJ-26483327
Molecular Weight	457.36
Formula	C22H25BrN4O2
CAS No.	807640-87-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Gijsen M, et al. HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer. PLoS Biol. 2010 Dec 21;8(12):e1000563.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BGB-102 807640-87-5 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors Src FLT VEGFR EGFR JNJ26483327 BGB 102 JNJ-26483327 BGB102 JNJ 26483327 inhibitor inhibit

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