Home Tools
Log in
Cart

Angiotensin II (3-8), human

Catalog No. T5824   CAS 12676-15-2
Synonyms: Angiotensin IV

Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Angiotensin II (3-8), human Chemical Structure
Angiotensin II (3-8), human, CAS 12676-15-2
Pack Size Availability Price/USD Quantity
5 mg 5 days $ 84.00
10 mg 5 days $ 134.00
25 mg 5 days $ 288.00
50 mg 5 days $ 432.00
100 mg 5 days $ 648.00
Bulk Inquiry
Get quote
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor.
In vivo Rats with CCH exhibited higher levels of Aβ42, p-tau and pro-inflammatory cytokines in the brain when compared with controls. Infusion of Ang IV significantly reduced the expression of pro-inflammatory cytokines in the brains of rats with CCH. Meanwhile, the reduction of pro-inflammatory cytokines levels caused by Ang IV was reversed by divalinal-Ang IV. During the treatment, the SBP in rats was not significantly altered[1]
Animal Research Eight weeks after bilateral CCA ligation surgery, rats were anaesthetized with 10% chloral hydrate and placed in a stereotactic frame. The scalp was reflected under sterile surgical conditions. A brain-infusion cannula coupled via vinyl tubing to an osmotic pump was implanted into the third cerebral ventricle by surgeons who were blinded to the experimental groups. Osmotic pumps were placed subcutaneously between the scapulae and used to infuse two doses of Ang IV (20 nM, 0.15 μl/h and 100 nM, 0.15 μl/h), divalinal-Ang IV (500 nM, 0.15 μl/h) or aCSF (0.15 μl/h) into the third cerebral ventricle, lasting for six weeks. Following this surgery, the wounds were carefully closed with sutures[1]
Synonyms Angiotensin IV
Molecular Weight N/A
CAS No. 12676-15-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Wang QG, Xue X, Yang Y,et al.Angiotensin IV suppresses inflammation in the brains of rats with chronic cerebral hypoperfusion[J].J Renin Angiotensin Aldosterone Syst. 2018 Jul-Sep;19(3):1470320318799587. 2. Park B M , Cha S A , Lee S H , et al. Angiotensin IV protects cardiac reperfusion injury by inhibiting apoptosis and inflammation via AT4R in rats[J]. Peptides, 2016, 79:66-74.

Related Products

Related compounds with same targets
Alacepril Azilsartan Medoxomil Perindoprilat Zabicipril Temocapril hydrochloride Benazeprilat Prosaikogenin G Vicenin 3

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Angiotensin II (3-8), human 12676-15-2 Endocrinology/Hormones RAAS Angiotensin II (3 8), human inhibit Inhibitor Angiotensin II (38), human Angiotensin Receptor Angiotensin IV Angiotensin II , human inhibitor

 

TargetMol