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AC710 Mesylate

Catalog No. T10228 CAS 1351522-05-8

AC710 Mesylate is a potent <a href="/target/PDGFR" style="display: inline; color: #c13a36">PDGFR</a> inhibitor (Kds: 0.6, 1.57, 1, 1.3, 1.0 nM for <a href="/target/FLT" style="display: inline; color: #c13a36">FLT</a>3, CSF1R, KIT, <a href="/target/PDGFR" style="display: inline; color: #c13a36">PDGFR</a>α and <a href="/target/PDGFR" style="display: inline; color: #c13a36">PDGFR</a>β).

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AC710 Mesylate, CAS 1351522-05-8

Pack Size	Availability	Price/USD
5 mg	8-10 weeks	$ 970.00
50 mg	8-10 weeks	$ 1,980.00
100 mg	8-10 weeks	$ 2,500.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AC710 Mesylate is a potent PDGFR inhibitor (Kds: 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ).
Targets&IC50	FLT3:0.6 nM (kd), c-Kit:1 nM (kd), PDGFRβ:1 nM (kd), PDGFRα:1.3 nM (kd), CSF1R:1.57 nM (kd)
In vivo	At 0.3 mg/kg of AC710, tumor growth is temporally inhibited, and growth resumes quickly thereafter. At 3 and 30 mg/kg of AC710, tumors regress completely, and the tumor volume stays suppressed for an extended period after dosing is halted. No bodyweight loss is observed in animals treated with AC710 at all doses, indicating that it is well tolerated in mice at efficacious doses. AC710 exhibits a significant impact on disease in a dose-dependent fashion in a mouse collagen-induced arthritis (CIA) model, at a dose as low as 3 mg/ kg for 15 days (day 0-14). AC710 (10 and 30 mg/kg) demonstrates equivalent or slightly better efficacy in reducing the joint swelling and inflammation than dexomethasone administered at a safe dose.
Animal Research	The antitumor efficacy of AC710 is assessed in a subcutaneous flank-tumor xenograft model in athymic nude mice using the MV4-11cell line. AC710 is dosed at 0.3, 3, and 30 mg/kg for 2 weeks. Tumor growth and body weight are monitored.

Molecular Weight	658.81
Formula	C32H46N6O7S
CAS No.	1351522-05-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Liu G, et al. Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. ACS Med Chem Lett. 2012 Sep 24;3(12):997-1002.

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AC710 SU14813 maleate Imatinib impurities3 CT52923 Dovitinib (TKI258) Lactate ZM323881 hydrochloride Toceranib Sunitinib-d10

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Keywords

AC710 Mesylate 1351522-05-8 Angiogenesis Tyrosine Kinase/Adaptors PDGFR AC-710 Mesylate Inhibitor inhibitor inhibit

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