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16α-hydroxy Dehydroepiandrosterone

Catalog No. T36920   CAS 1232-73-1

16α-hydroxy Dehydroepiandrosterone is a metabolite of the endogenous steroid hormone dehydroepiandrosterone .116α-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosteronevia16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as well as by fetal recombinant CYP3A7. It is a precursor to fetal estrogens, including estriol .2

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16α-hydroxy Dehydroepiandrosterone Chemical Structure
16α-hydroxy Dehydroepiandrosterone, CAS 1232-73-1
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 16α-hydroxy Dehydroepiandrosterone is a metabolite of the endogenous steroid hormone dehydroepiandrosterone .116α-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosteronevia16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as well as by fetal recombinant CYP3A7. It is a precursor to fetal estrogens, including estriol .2
Molecular Weight 304.43
Formula C19H28O3
CAS No. 1232-73-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Chloroform: 10 mg/mL

TargetMolReferences and Literature

1. Miller, K.K.M., Cai, J., Ripp, S.L., et al.Stereo- and regioselectivity account for the diversity of dehydroepiandrosterone (DHEA) metabolites produced by liver microsomal cytochromes P450Drug. Metab. Dispos.32(3)305-313(2004) 2. Hampl, R., and Starka, L.Minireview: 16α-Hydroxylated metabolites of dehydroepiandrosterone and their biological significanceEndocr. Regul.34(3)161-163(2000)

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Keywords

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