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1,3-Diphenylurea

Name: 1,3-Diphenylurea
Brand: TargetMol
SKU: T2716
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2716Cas No. 102-07-8

1, 3-Diphenylurea is involved with Epoxide hydrolase activity.

1,3-Diphenylurea

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Purity: 99.95%

Catalog No. T2716Cas No. 102-07-8

1, 3-Diphenylurea is involved with Epoxide hydrolase activity.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.95%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

1,3-Diphenylurea AI Summary

1,3-Diphenylurea demonstrates a wide range of bioactivities across various biological assays. It selectively increases Acetylcholine (AcCh) release in the brain, showing a notable 25.8% and 38.6% increase in K+ stimulated AcCh release in the cortex and hippocampus respectively, but also exhibits a decrease and moderate increase in basal release across these regions. It inhibits the NorA efflux pump in Staphylococcus aureus and demonstrates inhibitory activity against a variety of kinases and enzymes, including human recombinant soluble epoxide hydrolase (IC50 = 390.0 nM) and Mycobacterium tuberculosis EphB (IC50 = 19.0 nM). The compound also shows significant pharmacological effects such as inducing genomic imprint erasure, enhancing SMN2 expression, exhibiting cytotoxicity, and antimicrobial activities including antimalarial effects against Plasmodium falciparum, and antibacterial activity. Additionally, 1,3-Diphenylurea acts as a SARS-CoV-2 3CL-Pro protease inhibitor and exhibits membrane lysing activity in bacterial assays. These diverse bioactivities suggest its potential in neurostimulant, cognitive enhancement, antimicrobial therapy, and enzyme inhibition applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

1, 3-Diphenylurea is involved with Epoxide hydrolase activity.

Chemical Properties

Molecular Weight	212.25
Formula	C₁₃H₁₂N₂O
Cas No.	102-07-8
Smiles	O=C(Nc1ccccc1)Nc1ccccc1
Relative Density.	1.25 g/cm3. Temperature:20 °C.;1.25. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (259.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7114 mL	23.5571 mL	47.1143 mL	235.5713 mL
5 mM	0.9423 mL	4.7114 mL	9.4229 mL	47.1143 mL
10 mM	0.4711 mL	2.3557 mL	4.7114 mL	23.5571 mL
20 mM	0.2356 mL	1.1779 mL	2.3557 mL	11.7786 mL
50 mM	0.0942 mL	0.4711 mL	0.9423 mL	4.7114 mL
100 mM	0.0471 mL	0.2356 mL	0.4711 mL	2.3557 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc