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beta-MSH, human

Name: beta-MSH, human
Brand: TargetMol
SKU: TP1004
Price: 148 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1004Cas No. 17908-57-5

Alias β-MSH, human, β-Melanocyte Stimulating Hormone (MSH), human

beta-MSH, human is an endogenous peptide hormone and neurotransmitter produced by pro-opiomelanocortin (POMC), and is also an agonist of MC4-R (melanocortin 4 receptor).

beta-MSH, human

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Catalog No. TP1004Alias β-MSH, human, β-Melanocyte Stimulating Hormone (MSH), humanCas No. 17908-57-5

beta-MSH, human is an endogenous peptide hormone and neurotransmitter produced by pro-opiomelanocortin (POMC), and is also an agonist of MC4-R (melanocortin 4 receptor).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$148	-	In Stock
5 mg	$445	Inquiry	Inquiry
10 mg	$751	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description	beta-MSH, human is an endogenous peptide hormone and neurotransmitter produced by pro-opiomelanocortin (POMC), and is also an agonist of MC4-R (melanocortin 4 receptor).
In vitro	In human THP-1 monocytic cells, beta-MSH (0.1–100 nM) suppressed lipopolysaccharide (LPS, 10 ng/mL)-induced TNF-α production in a concentration-dependent manner, with maximal inhibition observed at 1–10 nM. beta-MSH did not significantly alter IL-10 expression but reduced proinflammatory cytokine production via activation of melanocortin receptors, particularly MC1R and MC3R[1].
In vivo	In mouse models, intraperitoneal injection of beta-MSH (0.5 mg/kg) significantly reduced plasma TNF-α levels induced by LPS (0.5 mg/kg) and attenuated inflammatory responses[1].
Synonyms	β-MSH, human, β-Melanocyte Stimulating Hormone (MSH), human

Chemical Properties

Molecular Weight	2660.92
Formula	C₁₁₈H₁₇₄N₃₄O₃₅S
Cas No.	17908-57-5
Smiles	C([C@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CN=CN2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]3N(C(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)N)=O)CCC(O)=O)=O)CCCCN)=O)CCCCN)=O)CC(O)=O)=O)CCC(O)=O)=O)=O)CCC3)CC4=CC=C(O)C=C4)=O)CCCNC(=N)N)=O)CCSC)=O)CCC(O)=O)=O)=O)=O)CCCNC(=N)N)=O)C(NCC(N[C@H](C(=O)N5[C@H](C(=O)N6[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CCCCN)=O)CCC6)CCC5)CO)=O)=O)C=7C=8C(NC7)=CC=CC8
Relative Density.	no data available
Sequence	Ala-Glu-Lys-Lys-Asp-Glu-Gly-Pro-Tyr-Arg-Met-Glu-His-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp
Sequence Short	AEKKDEGPYRMEHFRWGSPPKD

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (18.79 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.3758 mL	1.8790 mL	3.7581 mL	18.7905 mL
5 mM	0.0752 mL	0.3758 mL	0.7516 mL	3.7581 mL
10 mM	0.0376 mL	0.1879 mL	0.3758 mL	1.8790 mL

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and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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