Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 6-8 weeks | $ 135.00 | |
10 mg | 6-8 weeks | $ 229.00 | |
25 mg | 6-8 weeks | $ 432.00 | |
50 mg | 6-8 weeks | $ 585.00 | |
100 mg | 6-8 weeks | $ 855.00 | |
1 mL * 10 mM (in DMSO) | 6-8 weeks | $ 135.00 |
Description | (R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. |
Targets&IC50 | DBH (bovine):25.1 nM, DBH (human):18.3 nM |
In vitro | (R)-Nepicastat produces concentration-dependent inhibition of bovine and human dopamine-β-hydroxylase activity in vitro. [1] |
In vivo | (R)-Nepicastat (30 mg/kg, p.o.) reduces noradrenaline content, dopamine content and dopamine/noradrenaline ratio in mesenteric artery and left ventricle of spontaneously hypertensive rats (SHRs). [1] |
Synonyms | RS-25560-198 HCl |
Molecular Weight | 331.81 |
Formula | C14H15F2N3S·HCl |
CAS No. | 195881-94-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: <1 mg/mL
DMSO: 61 mg/mL (183.8 mM)
Ethanol: <1 mg/mL
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
(R)-Nepicastat HCl 195881-94-8 Metabolism Hydroxylase Nepicastat HCl (R)Nepicastat HCl RS-25560-198 HCl (R) Nepicastat HCl inhibitor inhibit