Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Steroid sulfatase/17β-HSD1-IN-1 is a highly effective inhibitor of both steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) activities, displaying an IC50 value of 28 nM against cellular human steroid sulfatase. This compound holds significant potential for investigating estrogen-dependent diseases [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | Steroid sulfatase/17β-HSD1-IN-1 is a highly effective inhibitor of both steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) activities, displaying an IC50 value of 28 nM against cellular human steroid sulfatase. This compound holds significant potential for investigating estrogen-dependent diseases [1]. |
In vitro | Steroid sulfatase/17β-HSD1-IN-1 (compound 13), at a concentration of 20 μM for a duration of 48 hours, demonstrates low cytotoxicity in HEK-293 cells, inhibiting cell growth by 12.8%. Additionally, when applied to T47D cells at concentrations ranging from 50 to 750 nM over a period of 0 to 25 minutes, it effectively inhibits cell growth and the activity of 17β-HSD1 in a time-dependent manner. |
In vivo | Steroid sulfatase/17β-HSD1-IN-1 demonstrates strong metabolic stability within the human hepatic S9 fraction, with a half-life (t1/2) of 47 minutes, and exhibits low intrinsic clearance (Clint) at 15 μL/min/mg protein [1]. |
Molecular Weight | 386.42 |
Formula | C19H18N2O5S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Steroid sulfatase/17β-HSD1-IN-1 inhibitor inhibit