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MPAM-15
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Catalog No. T218946 Copy Product Info
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MPAM-15 is a pan-opioid receptor positive allosteric modulator (PAM) capable of crossing the blood-brain barrier, exhibiting a selectivity of ≥16 times for μOR over δOR and κOR. It acts as an anti-hyperalgesic and analgesic, with observed activity in mouse models via both intracerebroventricular and intraperitoneal administration. MPAM-15 is applicable in pain-related research.
MPAM-15
Cas No. 312632-55-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | MPAM-15 is a pan-opioid receptor positive allosteric modulator (PAM) capable of crossing the blood-brain barrier, exhibiting a selectivity of ≥16 times for μOR over δOR and κOR. It acts as an anti-hyperalgesic and analgesic, with observed activity in mouse models via both intracerebroventricular and intraperitoneal administration. MPAM-15 is applicable in pain-related research. |
| In vitro | MPAM-15 (10 μM) can enhance the DAMGO-induced inhibition of cAMP in HEK293T cells expressing human μ-opioid receptors (μOR), increasing the agonist's pEC50 from 8.8 to 9.9. |
| In vivo | MPAM-15, when administered at doses of 1.5-5 μM via intracerebroventricular injection, induces a dose-dependent analgesic effect in mice during the 52℃ hot plate test. Conversely, MPAM-15 at doses of 15-30 mg/kg through intraperitoneal injection does not exhibit analgesic properties itself but significantly potentiates the analgesic effect of low-dose morphine while reducing morphine-induced side effects. |
| Molecular Weight | 450.95 |
| Formula | C27H27ClO4 |
| Cas No. | 312632-55-6 |
| Smiles | O=C1C2=C(OC3=C(C(=O)CC(C)(C)C3)C2C=4OC(=CC4)C=5C=CC=C(Cl)C5)CC(C)(C)C1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: MPAM-15 in vivo | MPAM-15 in vitro | MPAM-15 formula | MPAM-15 molecular weight
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