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MOTS-c, human Acetate
(Synonyms: MOTS-c, human Acetate (1627580-64-6 free)) Copy Product Info
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Synonyms: MOTS-c, human Acetate (1627580-64-6 free)
Catalog No. TP2312 Copy Product Info
Purity: 99.93%
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MOTS-c, human Acetate is a mitochondrial-derived peptide. MOTS-c, human acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c, human acetate induces glucose uptake and improves insulin sensitivity. MOTS-c, human acetate has implications in the regulation of obesity, diabetes, exercise, and longevity.
| Pack Size | Price | EUR Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | 48 € | In Stock | In Stock | |
| 5 mg | 91 € | In Stock | In Stock | |
| 10 mg | 131 € | In Stock | In Stock | |
| 25 mg | 235 € | In Stock | In Stock |
For In stock only · Estimated delivery: EUR Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.93%
Appearance:Solid
Color:White
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Chemical Properties
Storage & Solubility Information
| Description | MOTS-c, human Acetate is a mitochondrial-derived peptide. MOTS-c, human acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c, human acetate induces glucose uptake and improves insulin sensitivity. MOTS-c, human acetate has implications in the regulation of obesity, diabetes, exercise, and longevity. |
| In vitro | MOTS-c, human Acetate inhibits the folate cycle at the level of 5Me-THF, resulting in an accumulation of AICAR [5-aminoimidazole-4-carboxamide ribonucleotide). MOTS-c, human Acetate also increases cellular NAD+ levels, which are also nucleotide precursors[1]. |
| In vivo | MOTS-c, human Acetate injections in mice show activation of skeletal muscle AMPK and increased the level of its downstream glucose transporter GLUT4. MOTS-c, human Acetate may also act as a potential mitochondrial signal that mediates an exercise-induced mitohormesis response, thereby stimulating physiological adaptation and increased tolerance to exercise[1]. |
| Synonyms | MOTS-c, human Acetate (1627580-64-6 free) |
| Molecular Weight | 2234.64 |
| Formula | C103H156N28O24S2 |
| Smiles | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)N.CC(O)=O |
| Relative Density. | 1.31g/cm3 |
| Sequence | H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH |
| Sequence Short | MRWQEMGYIFYPRKLR |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mM, Sonication is recommended. H2O: 20 mg/mL (8.95 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O/DMSO
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Product Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: MOTS-c, human Acetate chemical structure | MOTS-c, human Acetate in vivo | MOTS-c, human Acetate in vitro | MOTS-c, human Acetate formula | MOTS-c, human Acetate molecular weight
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