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HCN-IN-1
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Catalog No. T218525 Copy Product Info
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HCN-IN-1 is a TLR4 inhibitor and a modulator of HCN2/HCN4 channels. It inhibits TLR4-mediated SEAP signaling activity and exerts its pharmacological effects by reducing HCN2 currents, altering their voltage-dependent activation and kinetics, and blocking HCN4 currents. HCN-IN-1 demonstrates analgesic, anti-inflammatory, and anti-anginal activities, making it applicable for research on inflammatory pain, neuropathic pain, heart failure, and inflammation.
HCN-IN-1
Cas No. 2234283-04-4
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | HCN-IN-1 is a TLR4 inhibitor and a modulator of HCN2/HCN4 channels. It inhibits TLR4-mediated SEAP signaling activity and exerts its pharmacological effects by reducing HCN2 currents, altering their voltage-dependent activation and kinetics, and blocking HCN4 currents. HCN-IN-1 demonstrates analgesic, anti-inflammatory, and anti-anginal activities, making it applicable for research on inflammatory pain, neuropathic pain, heart failure, and inflammation. |
| In vitro | HCN-IN-1 (compound 5) (0.39-100 μM; 24 h) inhibits the signal intensity of TLR4 alkaline phosphatase (SEAP) in HEK BLUE TLR4 cells in a concentration-dependent manner, with significant inhibition observed at concentrations of 25 μM or higher. |
| Molecular Weight | 484.07 |
| Formula | C28H38ClN3O2 |
| Cas No. | 2234283-04-4 |
| Smiles | ClC=1C=CC=CC1CN2N=C(C(=C2C)CN(C)CC(O)CCOC3=CC=C(C=C3)C(C)(C)C)C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: HCN-IN-1 in vitro | HCN-IN-1 formula | HCN-IN-1 molecular weight
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