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HBC-12551
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Catalog No. T217948 Copy Product Info
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HBC-12551 is an orally active BTK inhibitor with an IC50 of 1.31 nM for BTK and 2.18 nM for BTKC481S in HEK293 cells. It exhibits antitumor activity against diffuse large B-cell lymphoma.
HBC-12551
Cas No. 2963606-11-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | HBC-12551 is an orally active BTK inhibitor with an IC50 of 1.31 nM for BTK and 2.18 nM for BTKC481S in HEK293 cells. It exhibits antitumor activity against diffuse large B-cell lymphoma. |
| In vitro | HBC-12551 effectively inhibits BTK phosphorylation in HEK293 cells with an IC50 of 1.31 nM, as well as the phosphorylation of the BTK C481S mutant with an IC50 of 2.18 nM. In addition, after 72 hours of incubation, HBC-12551 significantly reduces cell viability in malignant B cell lines, including TMD8 (IC50 = 1.40 nM), TMD8-BTK-C481S (IC50 = 1.92 nM), OCI-Ly10 (IC50 = 1.86 nM), and REC-1 (IC50 = 3.11 nM). Moreover, HBC-12551 strongly suppresses B cell activation in human peripheral blood mononuclear cells (PBMCs), with an IC50 of 0.95 nM for CD69 expression following a 30-minute treatment. |
| In vivo | HBC-12551 (10-20 mg/kg; oral administration; once daily; 14 days) exhibits a potent dose-dependent inhibition of tumor growth in the TMD8 xenograft model. |
| Molecular Weight | 660.74 |
| Formula | C34H41FN8O5 |
| Cas No. | 2963606-11-1 |
| Smiles | C(N)(=O)C=1N(N=CC1NC=2N=C([C@H](OC)C)C(=CC2)N3CCN(CCOC)CC3)C4=CC=C(CNC(=O)C5=C(OC)C=CC(F)=C5)C=C4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: HBC-12551 in vivo | HBC-12551 in vitro | HBC-12551 formula | HBC-12551 molecular weight
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