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Goserelin acetate（65807-02-5 Free base）
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Catalog No. T36918L
Alias ICI-118630 acetate, ICI118630 acetate, Goserelin acetate（65807-02-5 Free base）
Goserelin acetate （ICI-118630 acetate） is a naturally occurring decapeptide, a GnRH (gonadotropin releasing hormone) agonist that reduces the production of sex hormones (testosterone and estrogen) for the treatment of prostate cancer, breast cancer and endometriosis.
Goserelin acetate（65807-02-5 Free base）
Goserelin acetate（65807-02-5 Free base）
😃Good
Purity: 99.77%
Catalog No. T36918LAlias ICI-118630 acetate, ICI118630 acetate, Goserelin acetate（65807-02-5 Free base）
Goserelin acetate （ICI-118630 acetate） is a naturally occurring decapeptide, a GnRH (gonadotropin releasing hormone) agonist that reduces the production of sex hormones (testosterone and estrogen) for the treatment of prostate cancer, breast cancer and endometriosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | Backorder | |
| 5 mg | $69 | Backorder | |
| 10 mg | $109 | Backorder | |
| 25 mg | $218 | Backorder | |
| 50 mg | $328 | Backorder | |
| 100 mg | $492 | Backorder |
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Purity:99.77%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Goserelin acetate （ICI-118630 acetate） is a naturally occurring decapeptide, a GnRH (gonadotropin releasing hormone) agonist that reduces the production of sex hormones (testosterone and estrogen) for the treatment of prostate cancer, breast cancer and endometriosis. |
| In vitro | Goserelin acetate (0.1-100 nM) treatment of pituitary cells revealed a biphasic regulation of LH and FSH secretion, with low concentrations promoting and high concentrations suppressing hormone release, indicating a concentration-dependent modulatory effect on pituitary hormone secretion[1]. |
| In vivo | In vivo, daily subcutaneous administration of Goserelin acetate (5 μg/kg for 21 days) in rats significantly suppressed plasma LH and FSH levels, demonstrating endocrine-suppressive activity via inhibition of the hypothalamic-pituitary-gonadal axis[1]. |
| Alias | ICI-118630 acetate, ICI118630 acetate, Goserelin acetate（65807-02-5 Free base） |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: 20 mg/mL, Sonication is recommended. H2O: 80 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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