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DHTP
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Catalog No. T218192 Copy Product Info
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DHTP is a selective allosteric inhibitor that suppresses the ATPase activity and microtubule depolymerization activity of kinesin-13. It exhibits inhibitory effects on Kif2a and MCAK with IC50 values of 1.2 μM and 4.6 μM, respectively, while not affecting other kinesin family members. DHTP modulates intracellular microtubule dynamics, resulting in reduced microtubule dynamism. This compound connects the overexpression of kinesin-13 with cancer and Paclitaxel resistance, making it a valuable tool for cancer research.
DHTP
Cas No. 1620225-37-7
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DHTP is a selective allosteric inhibitor that suppresses the ATPase activity and microtubule depolymerization activity of kinesin-13. It exhibits inhibitory effects on Kif2a and MCAK with IC50 values of 1.2 μM and 4.6 μM, respectively, while not affecting other kinesin family members. DHTP modulates intracellular microtubule dynamics, resulting in reduced microtubule dynamism. This compound connects the overexpression of kinesin-13 with cancer and Paclitaxel resistance, making it a valuable tool for cancer research. |
| Targets & IC50 | MCAK:4.6 μM |
| In vitro | DHTP (0.01-100 μM) selectively inhibits the ATPase activity of kinesin-13, with IC50 values of 4.6 μM for MCAK and 1.2 μM for Kif2a. At concentrations of 5 μM, 10 μM, and 20 μM, DHTP selectively reduces the rate of microtubule depolymerization induced by MCAK, decreasing it by 74% at 5 μM and by 89% at 10 μM, without affecting Eg5-driven sliding. Additionally, DHTP (10 μM; applied for 15-20 minutes) can modulate microtubule dynamics in Drosophila S2 cells, extending pause duration and promoting persistent growth. |
| Molecular Weight | 512.96 |
| Formula | C25H21ClN2O6S |
| Cas No. | 1620225-37-7 |
| Smiles | C(OC(C)C)(=O)C=1C(N2C(S/C(=C\C3=CC=C(OCC(O)=O)C=C3)/C2=O)=NC1)C4=CC=C(Cl)C=C4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: DHTP in vitro | DHTP formula | DHTP molecular weight
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