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CHI3L1-IN-7
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Catalog No. T218477 Copy Product Info
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CHI3L1-IN-7 is a selective inhibitor of CHI3L1, with a Kd of 7.40 μM and an IC50 of 15.4 μM. This compound disrupts the interaction between CHI3L1 and galectin-3, inhibits STAT3 phosphorylation, and reduces the viability of multicellular 3D glioblastoma spheroids. CHI3L1-IN-7 is useful for research involving glioblastoma and CHI3L1-mediated tumor immunoregulation.
CHI3L1-IN-7
Cas No. 2248987-74-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CHI3L1-IN-7 is a selective inhibitor of CHI3L1, with a Kd of 7.40 μM and an IC50 of 15.4 μM. This compound disrupts the interaction between CHI3L1 and galectin-3, inhibits STAT3 phosphorylation, and reduces the viability of multicellular 3D glioblastoma spheroids. CHI3L1-IN-7 is useful for research involving glioblastoma and CHI3L1-mediated tumor immunoregulation. |
| In vitro | CHI3L1-IN-7 (100 μM) binds to the CHI3L1 protein with a dissociation constant (K_d) of 7.40 μM. In AlphaLISA assays, CHI3L1-IN-7 inhibits the interaction between CHI3L1 and galectin-3, with an IC_50 of 15.4 μM. Additionally, at concentrations of 10-50 μM over 72 hours, this compound reduces the viability of multicellular 3D glioblastoma (GBM) spheroids and inhibits the phosphorylation of STAT3. |
| Molecular Weight | 357.43 |
| Formula | C17H19N5O2S |
| Cas No. | 2248987-74-6 |
| Smiles | O=C1C=2C=CSC2N=CN1CC(=O)NC=3C=NN(C3C)C4CCCC4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: CHI3L1-IN-7 in vitro | CHI3L1-IN-7 formula | CHI3L1-IN-7 molecular weight
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