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Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 198.00 | |
5 mg | In stock | $ 538.00 | |
10 mg | In stock | $ 778.00 | |
25 mg | In stock | $ 1,180.00 | |
50 mg | In stock | $ 1,590.00 | |
100 mg | In stock | $ 2,180.00 |
Description | Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis. |
Kinase Assay | Vedolizumab inhibition of high-affinity binding of MAdCAM-1 to human peripheral blood memory CD4+ T lymphocytes is tested. Peripheral blood (90 μL) is incubated with a saturating concentration (3 μg/mL) of MAdCAM-1-murine-Fc fusion protein and 4 mM MnCl2 in a final volume of 100 μL for 1 h at room temperature, in the presence or absence of vedolizumab. After washing with assay buffer, the cells are stained with fluorescentlabeled anti-mouse IgG for 15 min at room temperature. After washing again, cells are incubated with mouse serum for 10 min at room temperature, followed by staining with anti-CD4 and anti-CD45RO antibodies for 15 min at room temperature. After washing, red blood cells are lysed with BD FACS lysing solution and analyzed by flow cytometry in a FACSCalibur with CellQuest Pro software[1]. |
Molecular Weight | 147 kDa |
CAS No. | 943609-66-3 |
store at low temperature
store at -20 ℃
You can also refer to dose conversion for different animals. More
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Vedolizumab 943609-66-3 Cytoskeletal Signaling Integrin inhibitor inhibit