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Ustekinumab

Catalog No. T9913   CAS 815610-63-0

Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Ustekinumab Chemical Structure
Ustekinumab, CAS 815610-63-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 455.00
5 mg In stock $ 1,060.00
10 mg In stock $ 1,430.00
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AntibodyUnit: 89 mg/mL
Purity: 99.70%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.
Cell Research HUVECs are grown on calibrated glass coverslips to a confluency of 80%. Subsequently, cells are incubated with 200 μg/mL Ustekinumab AlexaFluor488 and Briakinumab AlexaFluor594 for 20 min at 37°C, pH 7.3, washed three times, and chased in fresh medium for an additional 20 min before fixation. Antibodies are directly labeled. FcRn binding is quality controlled by SPR analysis. Cells are then counterstained with anti-FcRn monoclonal antibody DVN22, followed by anti-mouse secondary antibodies conjugated to AlexaFluor647. Imaging is performed on a Leica SP8 confocal microscope[2].
Molecular Weight 148 kDa
CAS No. 815610-63-0

Storage

store at -20°C

TargetMolReferences and Literature

1. Montepaone M, et al. Profile of ustekinumab and its potential in the treatment of active psoriatic arthritis. Open Access Rheumatol. 2014 Feb 20;6:7-13. 2. Schoch A, et al. Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics. Proc Natl Acad Sci U S A. 2015 May 12;112(19):5997-6002.

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Oxelumab Muscone Y-320 BRD6989 SU5201 APY0201 Talacotuzumab GP130 receptor agonist-1

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Keywords

Ustekinumab 815610-63-0 Immunology/Inflammation Interleukin inhibit Interleukin Related Inhibitor inhibitor

 

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