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NUCC-390 dihydrochloride (1060524-97-1 free base)

Catalog No. T12269L CAS T12269L

Synonyms: NUCC-390 dihydrochloride

NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.

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NUCC-390 dihydrochloride (1060524-97-1 free base) Chemical Structure

NUCC-390 dihydrochloride (1060524-97-1 free base), CAS T12269L

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Purity: 98%

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Description	NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.
In vitro	NUCC-390 dihydrochloride (10 μM;?pre-treatment 30 mins) leads to increased levels of pERK, it has the capability of stimulating signaling activity downstream of CXCR4 receptors[1].NUCC-390 (10 μM;?2 hours) can induce CXCR4 receptor internalization, and non-treated cells exhibit some diffuse expression of CXCR4-YFP throughout the cytosol and clear expression in the cell membrane in HEK cells[1].
In vivo	NUCC-390 dihydrochloride?contributes to the functional and anatomical recovery of the neuromuscular junction (NMJ) following an acute nerve terminal damage by α-LTx in CD-1 mice.

Synonyms	NUCC-390 dihydrochloride
Molecular Weight	468.46
Formula	C23H35Cl2N5O
CAS No.	T12269L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Mishra RK, et al. Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonists.Sci Rep. 2016 Jul 26;6:30155.

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Keywords

NUCC-390 dihydrochloride (1060524-97-1 free base) T12269L Autophagy GPCR/G Protein Immunology/Inflammation CXCR NUCC-390 dihydrochloride NUCC 390 dihydrochloride (1060524 97 1 free base) NUCC390 dihydrochloride (1060524971 free base) inhibitor inhibit

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