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Z-Glycine

Name: Z-Glycine
Brand: TargetMol
SKU: T33604
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T33604Cas No. 1138-80-3

Alias N-Carbobenzoxyglycine, Carbobenzoxyglycine

Z-Glycine (Carbobenzoxyglycine) is a drug-lipid conjugates designed to promote brain penetration based on its lipophilicity and resemblance to lipids in biological membranes[1].

Z-Glycine

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Purity: 99.88%

Catalog No. T33604Alias N-Carbobenzoxyglycine, CarbobenzoxyglycineCas No. 1138-80-3

Z-Glycine (Carbobenzoxyglycine) is a drug-lipid conjugates designed to promote brain penetration based on its lipophilicity and resemblance to lipids in biological membranes[1].

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Appearance:solid

Color:White

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COA HNMR HPLC

Product Introduction

Z-Glycine AI Summary

Z-Glycine exhibits a range of biological activities and pharmacological effects. It demonstrates bioactivity in a papain-catalyzed hydrolysis assay with a Km value of 10,300 nM. Additionally, it shows significant anticonvulsant activity in various seizure models in mice, including maximal electroshock seizures and seizures induced by strychnine and 3-mercaptopropionic acid, suggesting its potential for managing neurological conditions associated with seizures. The compound also stimulates oxygen consumption activity of rat recombinant peptidylglycine alpha-amidating monooxygenase, with a Km value of 590,000 nM and a Vmax(app) value of 8.6/s, with a Vm(app) to Km(app) ratio of 1.5 x 10^4/M/s. Relative to hippuric acid, its activity is 2.4. In oncology studies, Z-Glycine exhibits antineoplastic activity against mouse EAC allografts in CF1 mice, significantly impacting packed cell volume and ascites volume, and achieving a high tumor growth inhibition rate of 97.0% on day 7 at a dose of 33 mg/kg. However, in the NAAA assay, the compound shows a weak or negligible inhibitory effect on N-acylethanolamine acid amidase (NAAA), with an IC50 value exceeding 100,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Z-Glycine (Carbobenzoxyglycine) is a drug-lipid conjugates designed to promote brain penetration based on its lipophilicity and resemblance to lipids in biological membranes[1].
Synonyms	N-Carbobenzoxyglycine, Carbobenzoxyglycine

Chemical Properties

Molecular Weight	209.2
Formula	C₁₀H₁₁NO₄
Cas No.	1138-80-3
Smiles	OC(=O)CNC(=O)OCC1=CC=CC=C1
Relative Density.	1.2944 g/cm3 (Estimated)
Sequence	Cbz-Gly-OH
Sequence Short	G

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (262.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7801 mL	23.9006 mL	47.8011 mL	239.0057 mL
5 mM	0.9560 mL	4.7801 mL	9.5602 mL	47.8011 mL
10 mM	0.4780 mL	2.3901 mL	4.7801 mL	23.9006 mL
20 mM	0.2390 mL	1.1950 mL	2.3901 mL	11.9503 mL
50 mM	0.0956 mL	0.4780 mL	0.9560 mL	4.7801 mL
100 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3901 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc